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Hodgkin's
Overview
Excellent videos explain the history of stem cell rescue, when
it's needed, what it is, and how it's improved over time.
Articles:
Advances in stem cell rescue have been steady and
not always reflected in the literature. The most appropriate
type of SCT is often based on individual risk factors, such as the
type of lymphoma, prior therapies, sensitivity to prior therapies,
one's age and performance to name just a few. Therefore
consulting experts is essential to making an informed choice in this
area in particular.
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Clinical outcome following autologous and allogeneic blood and
marrow transplantation for relapsed diffuse large-cell
non-Hodgkin's lymphoma
http://www.ncbi.nlm.nih.gov/pubmed/16920563
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A prognostic model for prolonged event-free survival after
autologous or allogeneic blood or marrow transplantation for
relapsed and refractory Hodgkin's disease.
http://www.ncbi.nlm.nih.gov/pubmed/15665852
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Autologous or allogeneic stem cell transplantation in
patients with Waldenstrom's macroglobulinemia.
http://www.ncbi.nlm.nih.gov/pubmed/16864055
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Long-term results favor allogeneic over autologous
hematopoietic stem cell transplantation in patients with
refractory or recurrent indolent non-Hodgkin's lymphoma.
http://www.ncbi.nlm.nih.gov/pubmed/12702528
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Syngeneic* Hematopoietic Stem-Cell Transplantation for Non-Hodgkin's
Lymphoma:
A Comparison With Allogeneic and Autologous Transplantation -
Readable
abstract
(Syngeneic. The donor is an identical twin of the
patient.)
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Summary of
Advantages and Disadvantages
Potential Advantages of Auto
Transplants:
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High
dose therapies made possible by prior harvesting and subsequent
engraftment may:
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decrease
risk of disease recurrence and/or curing aggressive component
of the disease. |
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produce
a durable remission. |
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Avoid Graft versus
Host disease
(compared to allogeneic SCT) |
Potential Problems with Auto
Transplants:
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Engrafted
cells can be contaminated with disease (compared to allogeneic
SCT) |
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Increases risk
of MDS/secondary AML |
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High Treatment Related Mortality
(TRM)
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Regimen related toxicity |
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Infection
during and following conditioning therapy until engraftment
takes. |
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Potential Advantages
of Allo Transplants:
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Tumor free
graft |
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Undamaged
Stem Cells |
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Avoidance
of MDS/secondary AML |
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Graft
versus lymphoma effect |
Potential Problems
with Allo Transplants:
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Lack of
suitable donors |
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High
Treatment Related Mortality
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Regimen
related toxicity |
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Infection |
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Graft
versus Host Disease (See GVHD for
details)
(not a risk for auto SCT type) |
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Adapted from: Allogeneic
Transplantation in Lymphoma
File Format: Microsoft Powerpoint 97 - View
as HTML |
