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Treatment > Comparing Auto/Allo Stem Cell Transplants

Last update: 11/27/2011

Topics

Articles | Summary of Advantages and Disadvantages

TOPIC SEARCH: Indolent NHL | Aggressive NHL | Hodgkin's

Overview

Excellent videos explain the history of stem cell rescue, when it's needed, what it is, and how it's improved over time.
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MSKCC About transplants (stem cell rescue) - an excellent overview!
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MSKCC: Transplant (stem cell rescue) innovations

Articles:

Advances in stem cell rescue have been steady and not always reflected in the literature.  The most appropriate type of SCT is often based on individual risk factors, such as the type of lymphoma, prior therapies, sensitivity to prior therapies, one's age and performance to name just a few.  Therefore consulting experts is essential to making an informed choice in this area in particular.

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Clinical outcome following autologous and allogeneic blood and marrow transplantation for relapsed diffuse large-cell non-Hodgkin's lymphoma http://www.ncbi.nlm.nih.gov/pubmed/16920563
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A prognostic model for prolonged event-free survival after autologous or allogeneic blood or marrow transplantation for relapsed and refractory Hodgkin's disease. http://www.ncbi.nlm.nih.gov/pubmed/15665852
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Autologous or allogeneic stem cell transplantation in patients with Waldenstrom's macroglobulinemia. http://www.ncbi.nlm.nih.gov/pubmed/16864055
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Long-term results favor allogeneic over autologous hematopoietic stem cell transplantation in patients with refractory or recurrent indolent non-Hodgkin's lymphoma. http://www.ncbi.nlm.nih.gov/pubmed/12702528
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Syngeneic* Hematopoietic Stem-Cell Transplantation for Non-Hodgkin's Lymphoma: 
 
A Comparison With Allogeneic and Autologous Transplantation - Readable abstract
(Syngeneic. The donor is an identical twin of the patient.)
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Autologous followed by Allogeneic (tandem) - Related PubMed abstracts

Summary of Advantages and Disadvantages


Potential Advantages of Auto Transplants:

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High dose therapies made possible by prior harvesting and subsequent engraftment may:
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decrease risk of disease recurrence and/or curing aggressive component of the disease. 

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produce a durable remission.

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Avoid Graft versus Host disease 
(compared to allogeneic SCT)

Potential Problems with Auto Transplants:

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Engrafted cells can be contaminated with disease (compared to allogeneic SCT)

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Increases risk of MDS/secondary AML 

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High Treatment Related Mortality (TRM)
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Regimen related toxicity

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Infection during and following conditioning therapy until engraftment takes.

 


Potential Advantages of Allo Transplants:

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Tumor free graft 

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Undamaged Stem Cells 

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Avoidance of MDS/secondary AML 

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Graft versus lymphoma effect

Potential Problems with Allo Transplants:

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Lack of suitable donors

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High Treatment Related Mortality
 
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Regimen related toxicity

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Infection

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Graft versus Host Disease (See GVHD for details)
(not a risk for auto SCT type)

Adapted from: Allogeneic Transplantation in Lymphoma
File Format: Microsoft Powerpoint 97 - View as HTML

 
Disclaimer:  The information on Lymphomation.org is not intended to be a substitute for 
professional medical advice or to replace your relationship with a physician.
For all medical concerns,  you should always consult your doctor. 
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