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Comparing Allo/Auto Stem Cell Transplants

  

 About Lymphoma > Treatment >  Bone Marrow and Stem Cell Transplants
 
Comparing Auto/Allo Stem Cell Transplants

Last update: 09/23/2005

TOPIC SEARCH: ASCO | Medscape | PubMed 
 AutoSCT vs.AlloSCT for relapsed indolent lymphoma - PubMed

Articles | Summary of Advantages and Disadvantages

Articles:
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Allogeneic vs. Autologous Transplantation for Indolent Non Hodgkin's Lymphoma, Bruce Cheson, MD National Cancer Institute John G. Gribben, MD Harvard Medical School  - WebCast PAL/Healthology
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Transplantation: Autologous vs. Allogeneic vs. Mini 
Hosted by: Sandra J. Horning, MD -  lymphoma.org.healthology.com 
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Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma -  Blood First Edition Paper July 31, 2003 - Summary | Full Text
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Syngeneic* Hematopoietic Stem-Cell Transplantation for Non-Hodgkin's Lymphoma: 
 
A Comparison With Allogeneic and Autologous Transplantation - Readable abstract
 (Syngeneic. The donor is an identical twin of the patient.)
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Autologous followed by Allogeneic (tandem) - Related PubMed abstracts
Summary of Advantages and Disadvantages

Potential Advantages of Auto Transplants:

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High dose therapies made possible by prior harvesting and subsequent engraftment may:
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decrease risk of disease recurrence and/or curing aggressive component of the disease. 

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produce a durable remission.

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Avoid Graft versus Host disease 
(compared to allogeneic SCT)

Potential Problems with Auto Transplants:

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Engrafted cells can be contaminated with disease (compared to allogeneic SCT)

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Increases risk of MDS/secondary AML 

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High Treatment Related Mortality (TRM)
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Regimen related toxicity

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Infection during and following conditioning therapy until engraftment takes.

 

Potential Advantages of Allo Transplants:

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Tumor free graft 

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Undamaged Stem Cells 

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Avoidance of MDS/secondary AML 

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Graft versus lymphoma effect

Potential Problems with Allo Transplants:

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Lack of suitable donors

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High Treatment Related Mortality
 
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Regimen related toxicity

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Infection

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Graft versus Host Disease (See GVHD for details)
(not a risk for auto SCT type)

Adapted from: Allogeneic Transplantation in Lymphoma
File Format: Microsoft Powerpoint 97 - View as HTML
 
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professional medical advice or to replace your relationship with a physician.
For all medical concerns,  you should always consult your doctor. 
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