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Clinical Trials > By Lymphoma type

Last update: 07/27/2011

Lymphoma studies in ClinicalTrials.gov

TYPES
 

Anaplastic Large Cell | AIDS-related | Childhood NHL | CLL/SLL | CNS | Cutaneous | Diffuse Large Cell | EBV-Related | Follicular | Hodgkins | Large B-Cell | Mantle Cell | Marginal Zone (MALT) | MDS | Mediastinal | NHL | 
T-Cell | Transformed to aggressive | Waldenström’s

 Lookup Trials by subtype and treatment status PAL

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or Clinical Trials of Interest  | Search Tools | Pipeline
 

Anaplastic 
Large Cell

Related Abstracts:

Adult PubMed

Childhood PubMed

T/null cell, primary cutaneous or systemic PubMed

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Investigational treatments for:
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All studies | CD30+ specified
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Recurrent ALC

AIDS/HIV -related

Related Abstracts:

PubMed 

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Investigational treatments for:
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All studies
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Newly diagnosed or untreated
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Recurrent

Burkitt's

Related Abstracts:

PubMed 

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Investigational treatments for:
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All studies

Childhood NHL

Related Abstracts:

PubMed 

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Investigational treatments for:
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All studies
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Newly diagnosed or untreated
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Recurrent 

CLL/SLL

Related Abstracts:

PubMed 

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Investigational treatments for:
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All studies  | Randomized
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Newly diagnosed or untreated
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Recurrent

CNS Lymphoma

Related Abstracts:

PubMed 

ASH 2009

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Investigational treatments (updated Jan 2010)
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All Studies
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Previously untreated CNS lymphoma (first line)
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Recurrent / Refractory
bullet Search also using TrialCheck.org  

Cutaneous lymphoma

Related Abstracts:

PubMed

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Investigational treatments for:
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All Studies
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Newly diagnosed or untreated
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Recurrent

Diffuse Large B Cell

Related Abstracts:

PubMed 

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Investigational treatments for:
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Newly diagnosed or untreated DLBCL  *
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With CNS involvement *
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Recurrent DLBCL all recruiting studies *

EBV-Associated Lymphomas

Related Abstracts:

PubMed

ASCO

  Medscape

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Investigational treatments for:
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All studies 

Follicular lymphoma

Related Abstracts:

PubMed
 
 

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Investigational treatments for:
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All newly diagnosed or untreated
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All recurrent
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Excluding chemotherapy (by request)

Hodgkins

Related Abstracts:

PubMed

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Investigational treatments for:
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All studies
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Newly diagnosed or untreated
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Recurrent | Lymphocyte predominant

Large B-cell

 

 

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Investigational treatments for:
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All studies
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Newly diagnosed or untreated (fixed 11-18)
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Recurrent
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Excluding chemotherapy (by request) 

Mantle Cell

Related Abstracts:

PubMed 

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Investigational treatments for:
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All studies
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Bexxar regimens (by request)
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Newly Diagnosed or untreated 
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Excluding chemotherapy (by request)
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Recurrent
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Excluding chemotherapy (by request)

Marginal Zone 
(MALT)

Related Abstracts:

PubMed 
  
Medscape

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Investigational treatments for:
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All studies
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Newly diagnosed or untreated | including adult NHL unspecified
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Recurrent 

MDS

Myelodysplastic Syndrome

Related Abstracts:

PubMed 
ASCO  
Medscape

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Investigational treatments for:
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MDS (Myelodysplastic Syndrome) - 
a complication of treatment for lymphoma

Primary Mediastinal
Large B-Cell

Related Abstracts:

ASH 2009

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Investigational treatments for:
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All treatments (check for aliases - too few results)

T-cell lymphoma

Related Abstracts:

PubMed

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Investigational treatments for:
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All studies
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NEW All studies (excluding Stem Cell Transplant) *
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Newly diagnosed or untreated 
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Recurrent
By Subtype (by request):
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Anaplastic Large Cell type: 
Newly diagnosed or  previously untreated
  AND Recurrent
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Angioimmunoblastic type | with stem cell transplant
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Cutaneous T-cell lymphomas *
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NK Cell 
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PTCL (Peripheral T-cell Lymphoma) *
By investigational agents:
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Anti-Tac  for Tac-expressing NHL, including T-cell NHL)
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Daclizumab (t-cell lymphomas)
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Denileukin diftitox - ONTAK (IL-2/diphtheria toxin fusion protein)

Possible mechanisms: "The IL-2 portion of the molecule targets the lymphoma cells by binding to the IL-2 receptor on the plasma membrane, and upon endocytosis, the diphtheria toxin is delivered to the lymphoma cells. Common side effects are nausea and vomiting, fever and flu-like symptoms. Other significant side effects include the cytokine release syndrome and vascular leak syndrome"-  ncbi.nlm.nih.gov/books

Topic Search on this agent: PubMed
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Depsipeptide (histone deacetylase inhibitor)

Possible mechanisms: induction of apoptosis, cell cycle arrest, and differentiation via the modulation of gene expression by histone acetylation

Topic Search on this agent: PubMed
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Immune therapies
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Pralatrexate  

Possible mechanisms: "Pralatrexate is a novel antifolate designed to have high affinity for the reduced folate carrier type 1 (RFC-1). Preclinical and clinical studies have demonstrated that pralatrexate has significant activity against TCL." - PMID: 16988580

Topic Search on this agent: PubMed
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Radioimmunotherapy 
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SAHA (Suberoylanilide Hydroxamic Acid)
  
Possible mechanisms: "SAHA treatment caused an accumulation of acetylated histones (H2B, H3, and H4), an increase of p21(WAF1) and bax proteins, a decrease of Stat6 and phospho-Stat6 proteins, and activation of caspase-3 in CTCL cells." - PMID: 16297208

Topic Search on this agent: PubMed
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T-cell antibodies  (biological agents that bind to receptors expressed on t-cells)
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SGN-30 (anti-CD30)

Transformed to aggressive

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Investigational treatments for indolent lymphomas 
transformed to aggressive:
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All studies 
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CLL (transformed Chronic Lymphocytic Lymphoma/Leukemia)
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Follicular
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Radioimmunotherapy

Waldenström’s

Related Abstracts:

PubMed

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Investigational treatments for:
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All studies
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newly diagnosed or untreated
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recurrent
 
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For all medical concerns,  you should always consult your doctor. 
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