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Clinical Trials of Interest - First Line Low Toxic

  

Clinical TrialsClinical Trials of Interest > First Line, Low Toxic

Last update: 11/17/2009

> First Line Low Toxic  | First Line Primary Therapy | Relapsed / refractory | Addressing other unmet needs

First Therapy (with minimal expected toxicity)

Also see Locating First Line Therapies for Lymphoma 

 

Follicular Lymphoma and other low grade lymphomas / CLL
 

New: Fenretinide and Rituxan

Condition:
B-cell lymphomas, including CLL
Rituxan followed by Maintenance (regularly scheduled) Rituxan
 
Condition: previously untreated stage III or IV NHL with low tumor burden.
Enzastaurin  (completed enrollment)
 
Condition:
Previously untreated follicular NHL in watchful waiting status


TOPIC SEARCH Mechanisms - PubMed
TOPIC SEARCH Outcome data - Medscape | PubMed
TOPIC SEARCH Safety or Toxicity -  PubMed 
Rituxan and Denileukin Diftitox 
  
Condition: Previously untreated Stage III or IV Follicular NHL
Biaxin-Based Antibiotic
 
Condition: Untreated advanced stage indolent Lymphoma

  First Line Low Toxic  | First Line Primary Therapy Relapsed / refractory
>
Addressing other unmet needs

Addressing Other Unmet Needs: 

TYPE: None-Interventional

Genomic and Biobank | Outcomes and Toxicities | Quality of Life | Screening Tests and Imaging

TOPIC SEARCH: Queries of ClinicalTrials.gov for Lymphoma (none interventional types)

 

Genomic and Biobank Studies
Genome Expression Study (highly recommended when it's time for a biopsy)

Rationale: The observed variability in the clinical course of follicular lymphoma, along with the diverse range of therapeutic options available,  makes it necessary for more refined  diagnostic stratification  (such as by gene expression or cytogenetic differences in the tumor cells).

Conditions: Lymphoma; Leukemia; Multiple Myeloma; Lymphoid Malignancies

Locations: 
  Nebraska Medical Center in Omaha,  
  Southwest Oncology Group centers- see for centers http://www.swog.org/ 
  the British Columbia Cancer Agency in Vancouver, Canada; 
  the Norwegian Radium Hospital in Oslo, Norway; 
  the University of Würzburg in Würzburg, Germany; 
  the University of Barcelona in Barcelona, Spain; and 
  St. Bartholomew's Hospital in London, England.

Background:  The Leukemia and Lymphoma Molecular Profiling Project (LLMPP), a collaboration of researchers in the United States, Canada, and Europe NCI investigators are working with researchers at the University of Nebraska Medical Center in Omaha to define the gene expression profiles of all types of human lymphoid malignancies. 

The project is supported by an international collaboration ...  The LLMPP uses "Lymphochip" cDNA (complementary DNA) microarrays, which are enriched in genes that are expressed in and/or function in lymphocytes. Lymphochip microarrays allow measurement of the RNA expression levels of the represented genes. Gene expression profiles developed as a result of this project may someday be used for disease classification (diagnosis), prognosis, and therapy selection. Already, results from the LLMPP indicate that these profiles can improve diagnostic accuracy and provide prognostic information. 

The LLMPP is initiating a multicenter clinical trial to evaluate a lymphoma diagnostic chip, called LymphDX, which was designed by the company Affymetrix in collaboration with NCI researchers using LLMPP data. The study will demonstrate the feasibility of disseminating the LymphDX microarray technology to all of the participating sites and will also evaluate the diagnostic utility of the LymphDX chip in a prospective study.
Source: cancer.gov  
Genetic Study of Chronic Lymphocytic Leukemia Families
Condition: CLL 
Location: U.T.M.D. Anderson Cancer Center, Houston,  Texas
Genetic Studies of X-Linked Lymphoproliferative Disease
Conditions: X-Linked Lymphoproliferative Disease; Lymphoproliferative Disease; Genetic Diseases, X-Linked
 
Outcomes and Toxicities
An Observational Study of Treatment, Outcomes, and Prognosis 
Condition: Lymphoma, Non Hodgkin
A Retrospective Study of Toxicity and Outcome of High Dose Chemotherapy With Autologous Stem Cell Transplant in Patients 
Condition: Non-Hodgkins Lymphoma
Prospective Data Collection of Newly Diagnosed Cases
Conditions: Hodgkin Disease; Lymphoma, Non-Hodgkin
A Retrospective Study of Toxicity and Outcome of High Dose Chemotherapy With Autologous Stem Cell Transplant in Patients With Hodgkin Lymphoma (HL).
Condition: Hodgkin Lymphoma
Study of Late-Occurring Complications in Childhood Cancer Survivors
Condition: Cancer
Clinical Evaluations and Laboratory Studies in Patients With Chronic Graft-Versus-Host Disease Who Have Undergone a Previous Donor Stem Cell Transplant
Condition: Cancer
Quality of Life
Health and Psychosocial Outcomes in Long-Term Lymphoma Survivors   

to identify chronic health conditions, psychological disease, quality of life issues, and patient preferences for survivorship care in patients who have survived aggressive lymphoma.
Caregiver Support in the Quality of Life of Patients Who Are Undergoing Donor Bone Marrow Transplantation
Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; ...
Nutritional Assessment Intervention to Improve Cancer-Related Fatigue
Conditions: Leukemia; Lymphoma; Fatigue
Screening Tests and Imaging
Dual Time Point PET Imaging in Lymphoma
Condition: Hodgkin's or Non-Hodgkin's Lymphoma
Screening Patients With Central Nervous System Tumors for Participation in National Cancer Institute Clinical Trials
Conditions: Brain and Central Nervous System Tumors; Lymphoma

 

 

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