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Types of Lymphoma > T-cell lymphoma >  NK Cell Lymphoma

Last update: 05/17/2017

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Extranodal NK/T-cell lymphoma, nasal type is an aggressive lymphoma that is very rare but more common in Asian and Hispanic communities. It can involve the nasal area, the trachea, the gastrointestinal tract, or skin.

See WHO Classification

"Normal Natural Killer cells are a certain type of white blood cell that attacks tumour cells and infected body cells by binding to a tumour cell and releasing lethal chemicals. Natural killer cells are thought to play a key role in cancer prevention by killing abnormal cells before they multiply and grow." - cancerweb.ncl.ac.uk

"Because NK-cell lymphomas express some T-cell markers, they may be mistakenly diagnosed as peripheral T-cell lymphomas if they are not investigated for the NK-cell-specific marker, CD56. Therefore the importance of immunophenotypic investigations of CD56 should be stressed. Also, the importance of clinical investigation of nasal/nasopharyngeal lymphomas should be stressed when NK-cell lymphoma is diagnosed involving the skin, because NK-cell lymphomas are often associated with the nasal and nasopharyngeal region." [6]

Also see  Peripheral T- cell lymphoma 

Clinical Trials

bullet NK Cell studies in ClinicalTrials.gov

Resources and News

2017: Targeting NK Cells for Anticancer Immunotherapy: Clinical and Preclinical Approaches. http://bit.ly/2pkoV6Y  (full text)
Blood, Eric Tse and Yok-Lam Kwong 2013:
How I treat NK/T-cell lymphomas http://bit.ly/1gDHMvT
Lima, 2013 review: Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis http://1.usa.gov/K5BdGs 
T Cell and NK Cell Lymphoproliferative Disorders 
John P. Greer, Marsha C. Kinney and Thomas P. Loughran, Jr.  ASH Edu book 2001

Related Abstracts

  1. Peripheral T-cell lymphoma [NK-type]
    Curr Oncol Rep. 2002 Sep;4(5):434-42. Review. PMID: 12162919  PubMed
  2. Characterization of novel natural killer (NK)-cell and gamma delta T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus  Blood
  3. Efficacy of ifosfamide, methotrexate, etoposide and prednisone (IMEP) chemotherapy in extranodal NK/T-cell lymphoma, nasal type.  ASCO 2004
  4. Dose-intensive CHOP chemotherapy followed by radiation for localized NK/T-cell lymphoma.  ASCO 2004
  5. Nasal and nasal-type T/NK-cell lymphoma with cutaneous involvement. J Am Acad Dermatol. 1999 May;40(5 Pt 2):850-6. PMID: 10321634  | Related articles
  6. Nasal-type NK/T cell lymphoma of the orbit with distant metastases.
    Hum Pathol. 2003 Mar;34(3):290-2. PMID: 12673566 | Related articles
  7. Article - Subtypes of Lymphoma  ASCO.org
  8. Long-term remission of blastic natural killer-cell lymphoma after autologous peripheral blood stem-cell transplantation. Am J Hematol. 2005 Oct;80(2):124-7. PMID: 16184583 | Related articles
  9. Extranodal natural killer/T-cell lymphoma, nasal type. Cancer. 2005 Dec 20;
    In the management of nasal NK/T-cell lymphoma, the RT field affected treatment outcomes. RT doses >/= 50 Gy resulted in favorable local control.  PMID: 16369986 | Related articles
  10. Case report: Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation  interscience.wiley.com  

    A 43-year-old female underwent allogeneic HSCT for advanced-stage, chemorefractory ENKL, and achieved complete response. In 4 months after the transplantation, however, the ENKL relapsed in multiple sites. These lesions markedly responded to the discontinuation of immunosuppressive agents and disappeared. Except for a temporal exacerbation of bronchiolitis obliterans organizing pneumonia, she has been free from disease for more than a year without other treatments against lymphoma. The clinical course of the current patient suggests the potent GVL effect against ENKL.
  11. Radiotherapy showed favorable outcome in treating early stage extranodal nasal-type NK/T-cell lymphoma in children and adolescents.  
  12. NEW Concurrent Radiation and Weekly Cisplatin Followed by VIPD in Newly Diagnosed, Stage IE to IIE, Nasal, Extranodal NK/T-Cell Lymphoma, J Clin Oncol. 2009. (n=32, newly diagnosed pt) PubMed - Related Articles 
  13. High Dose Chemotherapy (HDC) and Hematopoietic Stem Cell Transplant (HSCT) in Peripheral T Cell (PTCL), NK Cell and Ki-1 Anaplastic Large Cell Lymphoma (ALCL). 2001- 1174 


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