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Burkitt's lymphomas

  

About Lymphoma > Types of Lymphoma > Burkitt's Lymphoma

Last update: 04/22/2008

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Overview of Burkitt's Lymphoma
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Burkitt's are highly aggressive lymphomas.  As such, the goal of treatment is usually to cure the disease with aggressive therapy.  

From OncologyChannel: "Small noncleaved cell lymphoma (SNCL) is a classification that, in general, has been replaced by the terms Burkitt's lymphoma and Burkitt-like (or non-Burkitt's) lymphoma. In children, most SNCLs are Burkitt's lymphomas, whereas most adult SNCLs are Burkitt-like lymphomas.

Burkitt's lymphoma tends to occur most often in children and in adults with compromised immune systems. 

There are three distinct forms of this disease: endemic, sporadic, and immunodeficient.

Endemic Burkitt's lymphoma is seen among the young of equatorial Africa. It frequently affects the jaws of children with developing molar teeth; experts suggest that growth factors may be responsible for the site-specific nature of this tumor. 

Sporadic Burkitt's lymphoma often involves the abdomen, and it spreads to the bone marrow in about 20% of patients. 

Immunodeficient Burkitt's lymphoma affects patients with abnormal immune systems (e.g., patients with HIV)." 

Source: oncologychannel.com 

About  eMedicineBurkitts.org
Adult Burkitt's Leukemia and Lymphoma. 
Blood. 2004 Jul 20 [Epub ahead of print] PMID: 15265787
Resources
Follicular NHL, overview   e-Medicineinfobiogen 
Follicular NHL, technical  Umdnj.edu | Cancer Genetics Web 
Progression of follicular large cell lymphoma to Burkitt's lymphoma.
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Related Resources
Treatment overview  PAL
An international evaluation of CODOX-M and CODOX-M alternating with IVAC in adult Burkitt's lymphoma: results of United Kingdom Lymphoma Group LY06 study.
Ann Oncol. 2002 Aug;13(8):1264-74.  PMID: 12181251
Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol. Ann Oncol. 2005 Dec;16(12):1928-35. Epub 2005 Nov 10.
PMID: 16284057 | Related articles
Sequential doxorubicin and topotecan in relapsed/refractory aggressive Burkitt's / DLBCL: Results of CALGB 59906. Leuk Lymphoma. 2006 Aug;47(8):1511-7.  PMID: 16966261 

Five (of 26) patients (20%, 95% confidence interval 0.07, 0.42) responded with two (8%) complete remissions and three (12%) partial remissions; an additional four (16%) patients had stable disease. Both patients achieving a complete remission had Burkitt's lymphoma. There were no treatment-related deaths. In conclusion, the combination of doxorubicin and topotecan is well tolerated and has modest activity in relapsed/refractory NHL, with occasional patients having a prolonged remission. The activity in Burkitt's lymphoma should be investigated further.
ClinicalTrials.gov (easy and comprehensive) searches by
All studies for Burkitt's listed in ClinicalTrials.gov 
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Research News

Research News
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Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia. Cancer. 2006 Feb 24; PMID: 16502413
c-Flip protein expression in Burkitt's lymphomas is associated with a poor clinical outcome. Br J Haematol. 2005 Mar;128(6):767-73. PMID: 15755279
High response rate and manageable toxicity with an intensive, short-term chemotherapy programme for Burkitt's lymphoma in adults. Br J Haematol. 2004 Sep;126(6):815-20. PMID: 15352985 | Related articles
Modified magrath regimens for adults with Burkitt and Burkitt-like lymphomas: preserved efficacy with decreased toxicity. Leuk Lymphoma. 2004 Apr;45(4):761-7. PMID: 15160953
Epstein-Barr virus (EBV) associated lymphomas  Related abstracts
The three main types of EBV-associated B-cell lymphoma are Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas
Burkitt's lymphoma: single-centre experience with modified BFM protocol.
Clin Lab Haematol. 2002 Apr;24(2):111-4. PMID: 11985557  PubMed
 
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