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Burkitt / Burkitt-like Lymphoma
Last update:
06/16/2013
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Topics
Overview
| Treatment &
Clinical
Trials | Research News
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PubMed:
Diagnosis
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Review
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Therapies
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Prognosis |
Refractory
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Overview of Burkitt's Lymphoma
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Burkitt are highly
aggressive lymphomas. As such, the goal of treatment
is usually to cure the disease with aggressive
therapy.
From OncologyChannel: "Small noncleaved cell lymphoma (SNCL) is a classification that, in general, has been replaced by the terms
Burkitt lymphoma and Burkitt-like (or non-Burkitt) lymphoma.
In children, most SNCLs are
Burkitt lymphomas, whereas most adult SNCLs are Burkitt-like lymphomas.
Burkitt's lymphoma tends to occur most often in children and in adults with compromised immune systems.
There are three distinct forms of this disease: endemic, sporadic, and immunodeficient.
Endemic Burkitt lymphoma is seen among the young of equatorial Africa. It frequently affects the jaws of children with developing molar teeth; experts suggest that growth factors may be responsible for the site-specific nature of this tumor.
Sporadic Burkitt lymphoma often involves the abdomen, and it spreads to the bone marrow in about 20% of patients.
Immunodeficient
Burkitt lymphoma affects patients with abnormal immune systems (e.g., patients with HIV)."
Source:
oncologychannel.com
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See
NCCN.org guidelines, page 57
for combination protocols used with curative intent, such as:
CALGB 9251 or CODOX-M, or HyperCVAD or dose-adjusted EPOCH
Protocols may be adjusted based on high or low risk disease.
(free registration required) |
NCCN.org notes that CHOP-R is not
adequate.
In the News:
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Haematologica. 2013 Jun 10.: High cure rates in Burkitt
lymphoma and leukemia: NILG study of the German short intensive
rituximab-chemotherapy program.
http://1.usa.gov/12AKHRQ
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ARCHIVED under
Treatments below. |
Resources
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The Oncologist, 2006, Ferry:
Burkitt’s Lymphoma: Clinicopathologic Features and Differential
Diagnosis
theoncologist |
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Burkitt Lymphoma in Adults,
Hematology 2008
asheducationbook
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Molecular diagnosis (to distinguish from
DLBCL)
nejm.org |
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Burkitt’s Lymphoma: A Review of the
Epidemiology
kma.org.pdf
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Burkitt-like lymphoma of T-cell type
ncbi.nlm.nih.gov
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The Burkitt-like lymphomas
bloodjournal.hematologylibrary.org
Southwest Oncology Group study delineating phenotypic,
genotypic,
and clinical features
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Treatments
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Treatments
Also
see:
Questions for your doctor - Patients
Against Lymphoma
General, Treatment, Side Effects, and Tests
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TOPIC
SEARCH:
PubMed: Review
| Therapies |
Outcomes
Related Resources and Reports
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The role of hematopoietic SCT in adult Burkitt lymphoma
macopscomments.Article.pdf |
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Evaluation
of the addition of rituximab to CODOX-M/IVAC for
Burkitt's lymphoma:
Life After Cancer | National Comprehensive Cancer
Network
http://bit.ly/qfDMrn
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Evaluation of the addition of rituximab to CODOX-M/IVAC for
Burkitt's lymphoma: a retrospective analysis
annonc.oxfordjournals.org |
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Efficacy and toxicity of dose-adjusted
EPOCH-rituximab in adults with newly diagnosed
Burkitt lymphoma, 2007
ascopubs.org
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Evaluation of the addition of rituximab to CODOX-M/IVAC for
Burkitt's lymphoma: a retrospective analysis
annonc.oxfordjournals.org
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Treatment of Burkitt's/Burkitt-like lymphoma in adolescents
and adults: a 20-year experience from the Norwegian Radium
Hospital with the use of three successive regimens
http://annonc.oxfordjournals.org
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ASH: Chemotherapy Regimen Induces Complete Remissions in Burkitt's
By Neil Osterweil, Senior Associate Editor, MedPage Today
Published: December 11, 2006
.medpagetoday.com
A novel approach to Burkitt's lymphoma, using a regimen designed for large B-cell lymphomas, led to complete remissions in all patients in a small study, investigators reported here.
In a study of 19 patients with Burkitt's, the highly aggressive B-cell lymphoma, all 19 treated with
dose-adjusted EPOCH with Rituxan (rituximab) had a complete remission, with few of the adverse events associated with standard chemotherapy for Burkitt's lymphoma, reported Kieron Dunleavy, M.D., of the National Cancer Institute in Bethesda, Md., and colleagues.
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An international evaluation of CODOX-M and
CODOX-M alternating with IVAC in adult Burkitt's lymphoma: results
of United Kingdom Lymphoma Group LY06 study.
Ann Oncol. 2002 Aug;13(8):1264-74.
PMID:
12181251 |
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Burkitt lymphoma in adults: a prospective study
of 72 patients treated with an adapted pediatric LMB protocol. Ann
Oncol. 2005 Dec;16(12):1928-35. Epub 2005 Nov 10.
PMID:
16284057 |
Related
articles |
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Sequential doxorubicin and topotecan in
relapsed/refractory aggressive Burkitt's / DLBCL: Results of CALGB
59906. Leuk Lymphoma. 2006 Aug;47(8):1511-7.
PMID:
16966261
Five (of 26) patients (20%, 95% confidence interval
0.07, 0.42) responded with two (8%) complete remissions and three
(12%) partial remissions; an additional four (16%) patients had
stable disease. Both patients achieving a complete remission had
Burkitt's lymphoma. There were no treatment-related deaths. In
conclusion, the combination of doxorubicin and topotecan is well
tolerated and has modest activity in relapsed/refractory NHL, with
occasional patients having a prolonged remission. The activity in
Burkitt's lymphoma should be investigated further.
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ClinicalTrials.gov (easy and
comprehensive) searches by
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Research News
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Research News
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Burkitt's Like Lymphoma in Patients with and Without Hiv
Infection a report of 33 patients from north-east Italy informaworld.com/
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Adult Burkitt's Leukemia and Lymphoma.
Blood. 2004 Jul 20 [Epub ahead of print] PMID:
15265787
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Chemoimmunotherapy with hyper-CVAD plus rituximab for the
treatment of adult Burkitt and Burkitt-type lymphoma or acute
lymphoblastic leukemia. Cancer. 2006 Feb 24; PMID:
16502413
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c-Flip protein expression in Burkitt's
lymphomas is associated with a poor clinical outcome. Br J
Haematol. 2005 Mar;128(6):767-73. PMID:
15755279
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High response rate and manageable toxicity with
an intensive, short-term chemotherapy programme for Burkitt's
lymphoma in adults. Br J Haematol. 2004 Sep;126(6):815-20. PMID:
15352985 | Related
articles
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Modified
magrath regimens for adults with Burkitt and Burkitt-like
lymphomas: preserved efficacy with decreased toxicity. Leuk
Lymphoma. 2004 Apr;45(4):761-7. PMID:
15160953
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Epstein-Barr virus (EBV) associated lymphomas
Related
abstracts
The three main types of EBV-associated B-cell lymphoma are
Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas
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Burkitt's
lymphoma: single-centre experience with modified BFM protocol.
Clin Lab Haematol. 2002 Apr;24(2):111-4. PMID: 11985557 PubMed
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