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2003

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• Stage IV indolent lymphoma: A randomized study of concurrent vs. sequential use of FND chemotherapy (fludarabine, mitoxantrone, dexamethasone) and rituximab (R) monoclonal antibody therapy, with interferon maintenance - ASCO 2003

• BEXXAR: Title: ASH: New Analysis Confirms Most Complete Remissions in Follicular non-Hodgkin's Lymphoma Persist for Years Following Single Treatment with Bexxar (Tositumomab and Iodine I 131 Tositumomab) - docguide

• Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type.
  Blood. 2003 Oct 15;102(8):2741-5. Epub 2003 Jul 03. PMID: 12842999 | Related abstracts
   
  Lay perspective: These findings suggest that Rituxan should be given full consideration as treatment for MALT prior to chemotherapy.

• Managing Infections in Patients With Hematologic Malignancies
  Content Development Co-Chairs: Kenneth V. Rolston, MD, John R. Wingard, MD - Medscape 2003 (free login req.)

• Immunomedics in Discussions to Regain Development Rights From Amgen for Epratuzumab (anti-cd22) - stockworld 

• Rituxan failed to show improved survival as a maintenance therapy in aggressive NHL. - 
  November 10, 2003 - commentwire.com

• ViaCell Initiates Phase I/II Trial of Amplified Cord Blood Stem Cells as Therapy for Adults with Leukemia and Other Hematologic Cancers - viacellinc.com

• A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a tumor selective radiation sensitizer detectable by magnetic resonance imaging. 
  Clin Cancer Res. 1999 Apr;5(4):739-45. PMID: 10213207 | Related abstracts 
  This item is not lymphoma-specific, but bears watching because of the potential it has to be taken up selectively in tumor cells, it's short half life, and because uptake can be verified by MR imaging. 

• Methotrexate Induction Therapy Followed by High-Dose Chemotherapy ... 
  Doctor's Guide  ... followed by high-dose chemotherapy with autologous stem-cell rescue
  may be a feasible treatment approach for primary central nervous system
  (CNS) lymphoma ... - docguide.com  (press release)

• Cigarette Smoking in Women Increases Risk for Follicular Lymphoma.
  United States Researchers from Yale University have reported that long-term cigarette smoking in women increases the risk of developing follicular lymphoma. - cancerconsultants.com

• SV40: an emerging pathogen that's been around for fifty years - vaccinationnews - 2003 July/18 | 
  Also see SV40 Updates - PAL

• Clinical Anti-Cancer ... PPI-2458 (targeting MetAP2) has recently entered a Phase I clinical study for the treatment of NHL at the Dana-Farber Cancer Institute, in Boston, MA.- businesswire | Related abstracts

• Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical Outcome. J Clin Oncol. 2003 Nov 15;21(22):4157-4164. PMID: 14615444

• Study Links Psoriasis to Lymphoma Cancers 
  Yahoo News CHICAGO (Reuters) - Psoriasis sufferers may later develop lymphoma cancers
  at nearly three times the rate of people who do not have the red and scaly skin ... news.yahoo.com 

• Primary Central Nervous System Lymphoma: Results of a Pilot and Phase II Study of Systemic and Intraventricular Chemotherapy With Deferred Radiotherapy. J Clin Oncol. 2003 Nov 3 
  PMID: 14597744 | More

• PET imaging to predict responders and non-responders to high dose condition therapy for SCT - hematology.org

• Will Medicare/Medicaid reimburse for Zevalin and Bexxar? Status of decision here.
  Also how to make public comment about off-label use of these agents, which could be
  very important to folks with MCL, and CLL/SLL, etc. -  cms.hhs.gov 

• HLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with hematologic malignancies. Blood. 2003 Sep 15;102(6):2021-30. Epub 2003 Jun 05. PMID: 12791654 | More

• Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter-induced mucosa-associated lymphoid tissue lymphoma (full text) - PNAS Feb_2003

• Predicting response to Rituxan: Variation in gene expression patterns in follicular lymphoma and the response to rituximab -  Sean P. Bohen, Olga G. Troyanskaya, Orly Alter, Roger Warnke, David Botstein, Patrick O. Brown, and Ronald Levy (full text) - PDF

• Overcoming drug resistance: Sensitization of ara-C-resistant lymphoma cells by a SATE pronucleotide analogue. Int J Cancer. 2003 Oct 20;107(1):149-54. PMID: 12925971 | Abstracts 

  • Added to Treatments > Refractory disease

• Importing drugs from Canada:  The hidden price of price control on prescription drugs 
  - pacificresearch.org | techcentralstation | nurseweek.com 

• New Protocol: Mitoxantrone-cyclophosphamide-rituximab: an effective and safe combination for indolent NHL. Hematol Oncol. 2003 Sep;21(3):99-108. PMID: 14579238 

  • Added to Treatments > Treatment Settings (abstracts)

• Autoimmune cytopenia does not predict poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma. Am J Hematol. 2003 Sep;74(1):1-8. PMID: 12949883 | Abstracts

• Stage III follicular lymphoma: long-term follow-up and patterns of failure.
  Int J Radiat Oncol Biol Phys. 2003 Nov 1;57(3):748-54. PMID: 14529780

  • Added to Treatments > Treatment Settings (abstracts)

• Predictive value of early 18F-fluoro-deoxyglucose positron emission tomography (PET) in chemosensitive relapsed lymphoma. Br J Haematol. 2003 Oct;123(2):282-7. PMID: 14531910

  • Added to PET imaging

• Pegfilgrastim (Neulasta) for chemo-induced neutropaenia - docguide.com 10_03

• Alternation of epirubicin and mitoxantrone in CHOP-like regimens retains efficacy and reduces overall toxicity in elderly patients with high and intermediate grade non-Hodgkin lymphomas. Leuk Lymphoma. 2002 Dec;43(12):2319-24. PMID: 12613518

• Avoiding in-flight colds - travel.nzoom.com  
  Also since  it's flu season, a good time to review the  Immunization Guide

• Selenium May Raise Skin Cancer Risk -  Reuters.com Oct_03

  • Added to CAM - Selenium

• Bexxar® may Improve Survival in Autologous Stem Cell Transplants for Follicular Lymphoma - cancerconsultants.com 

• Stanford Research Builds Link between Sleep, Cancer Progression - sciencedaily.com 

• Inex Pharmaceuticals initiates submission of New Drug Application for Onco TCS to the United States FDA - newswire.ca Oct_03

• Transimmunization - an investigational immunotherapy that utilizes photopheresis - zwire.com

• Predicting response to Rituxan: Two Immunoglobulin G Fc Receptor Polymorphisms (expressed on effector cells) Independently Predict Response  in Pts With Follicular NHL. J Clin Oncol. 2003 Sep 15 - PMID: 12975461

• Doctors' knowledge of radiation exposure: questionnaire study, 2003  - BMJ

• The Dual Association between Lymphoma and Autoimmunity - rheuma21st.com

• Steroid withdrawal - medicinenet.com

• Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphoma. Cancer. 2003 Sep 1;98(5):993-1001. PMID: 12942567

• Molecular Diagnosis of Primary Mediastinal B Cell Lymphoma Identifies a Clinically Favorable Subgroup of Diffuse Large B Cell Lymphoma Related to Hodgkin Lymphoma - jem.org 9_15_03

• Painkillers May Raise Lymphoma Risk for Women - paktribune.com 9_14_03

• Corixa wins full reimbursement for lymphoma drug (Bexxar)  - Seattle Times 9-12_03

• Measuring the Benefits of Cancer Therapy - abcnews.go.com

• Preclinical: Fully human anti-MHC class II monoclonal antibody, 1D09C3, may have potent synergistic activity with Rituxan  - press release

• Mechanism Found that Weakens Caregivers' Immune Status: 
  Interleukin-6 associated with diabetes and other serious diseases - acs.ohio-state.edu Jun_03

• Correlation of Tumor Radiation-Absorbed Dose with Response Is Easier to Find in Previously Untreated Patients  Kenneth F. Koral, PhD, Mark S. Kaminski, MD and Richard L. Wahl, MD - Journal of Nuclear Medicine

• Phase II study of alemtuzumab in chronic lymphoproliferative disorders.
  Cancer. 2003 Aug 15;98(4):773-8. PMID: 12910522 | Related

• Multicenter study of pegylated liposomal doxorubicin in patients with cutaneous T-cell lymphoma. Cancer. 2003 Sep 1;98(5):993-1001. PMID: 12942567

• Results Never Reported for Many Large Cancer Trials 
  Loss of Information May Affect How Doctors Treat Patients ACS - 2003/08/15

• Dioxin emissions from a solid waste incinerator and risk of non-Hodgkin lymphoma. Epidemiology. 2003 Jul;14(4):392-8. PMID: 12843761

• Clinical trials: Non-chemo Rituxan combination studies - ClinicalTrials.gov

• Fatigue and Quality of Life: Lessons from the Real World - The Oncologist, Feb_003 The impact of fatigue on the quality of life of oncology patients is substantial and under-recognized.

• Oncologists disagree about benefits of Internet to  patients - CA Cancer J Clin 2003

• Immunotherapy, Past Present and Future - medscape (free login req.)

• Immunotherapy w/ autoBMT - medscape (free login req.) 

• Bispecific antibodies - novel investigative  treatment for refractory Hodgkin's disease - related abstracts

• Treatment of relapsed B-cell non-Hodgkin's lymphoma with a combination of  rituxan and G-CSF: final report on safety and efficacy. Leukemia. 2003 Aug;17(8):1658-1664. PMID: 12886256 - PubMed | Related abstracts

• Combretastatin, an antiangiogenic agent for NHL?- Related PubMed abstracts

• Corixa and GlaxoSmithKline Announce Commercial Availability of BEXXAR Therapeutic Regimen - businesswire

• Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma -  Blood First Edition Paper July 31, 2003 - Summary

• Utility of surgical resection with or without radiation therapy in patients with low-grade gastric mucosa-associated lymphoid tissue lymphoma Pier Luigi Zinzani, Monica Tani, Enza Barbieri, Vittorio Stefoni, Lapo Alinari, Michele Baccarani - Haematologica.org 

• Rituximab therapy for follicular lymphoma: a comprehensive review of it's efficacy as primary treatment, treatment for relapsed disease, re-treatment and maintenance - Yossi Cohen, Philippe Solal-Céligny, Aaron Polliack  - abstract |  PDF | PDF-Help  07_03

• Potential role of pharmacogenomics (how genetics affects drug metabolism)  in reducing adverse  drug reactions: a systematic review. JAMA. 2001 Nov 14;286(18):2270-9. Review. PMID: 11710893  - PubMed | Related abstracts

• Treating Aggressive Non-Hodgkin's Lymphoma -  Non-Hodgkin's Lymphoma: Where Do We Stand Today? - John D. Hainsworth, MD - Medscape  2003 (free login req.)

• Voluntary Death: A Comparison of Terminal Dehydration and Physician-Assisted Suicide,  Annals of Internal Medicine  - ACP

• Hyperactive stress response to interferon-alpha predicts development of depression - ASCO 7_03

• Interferon interacts with p53 to provide defense against cancer and viruses - ASCO 7_03

• Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen. Bone Marrow Transplant. 2003 Apr;31(8):663-6. PMID: 12692606 - PubMed

• RNA interference research is rapidly evolving, and the phenomenon remains little-understood. But what is known is that these double-stranded snippets effectively silence targeted genes. And that makes the experts optimistic. - Health AP 7_03

• Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system? - bloodjournal.org 

• Tumor-Starving Drugs Hit Their Stride -Researchers - Reuters 7_03

• Worry Over a Carcinogen (acrylamide) Spurs Research Blitz - washingtonpost.com 7_03

• Inhibition of the proteasome induces cell cycle arrest and apoptosis in mantle cell lymphoma cells. Br J Haematol. 2003 Jul;122(2):260-8. PMID: 12846895 - PubMed

• Involved-field radiotherapy for advanced Hodgkin's lymphoma.
  N Engl J Med. 2003 Jun 12;348(24):2396-406. PMID: 12802025 - PubMed

• Guidance for Industry and FDA - Interim Evidence-based Ranking System for Scientific Data - fda.gov 

• Study: 1 in 3 doctors hides options - Physicians withhold information on treatment choices - MSN.com 7_03

• FDA Acts to Provide Better Information to Consumers on Trans Fats - FDA.gov
  Note: trans fats are also associated with increased risk of NHL in women.

• Profiling cancer to find better treatments - sfgate.com

• Non-Hodgkin's Lymphoma: The Evolution of Therapy - Medscape (free login req.) 07_03_03 

• FDA Approves Bexxar in Patients With Follicular Non-Hodgkin's Lymphoma - DoctorsGuide 6_03 | ODAC transcripts - PDF

• Best Hospitals - usnews.com 

• ASCO 2003 - 105 Lymphoma abstracts - Lymphomation.org

• Untangling the Roots of Cancer - Sci Amer. 07_03

• Ocular Adnexal Lymphomas Linked to Chlamydia psittaci Infection - common in pet birds - May respond to antibiotic treatment- ASCO 2003 

• NCI and FDA Announce Joint Program to Streamline Cancer Drug Development - Cancer.gov 5_30_03

• Gene profiles predict survival - NCS Infoservices, 04_02
  The activity of as few as 17 genes can be used to predict lymphoma patients' response to treatment, scientists reported at the 18th UICC International Cancer Congress in Oslo this week.

• Management Strategies for Chronic Lymphocytic Leukemia CME Author: Michael J. Keating, MB, BS - Medscape (free login req.) 06_03

• SV40 update - Simian virus 40 in human cancers Jun_03

• Medicare Changes Coming? Some in Congress Say "Yes" - ACS

• DNA arrays diagnose, predict survival for Sezary syndrome cancer patients - 
  New technology validated, dozens of potential drug targets identified - Eurekalert.org Jun_03

• ASCO 2003 - Report on ONTAK (denileukin diftitox) -  biologic activity in CLL;  how patients tolerated treatment  - BusWire

• Millennium says anti-cancer proteasome inhibitor safe over longer term - ASCO

• ASCO 2003 -  Oncophage (for indolent fNHL) in the Phase II trial, there were responses observed ...  suggesting the potential utility of the vaccine in patients with minimal residual disease. BusWire

• ASCO 2003 - SGN-30 is a genetically engineered antibody in clinical trials for the treatment of patients with CD30+ hematologic malignancies such as Hodgkin's disease, anaplastic large cell lymphoma and other types of lymphomas. - Buswire

• ASCO 2003 -  In Vitro Studies Demonstrate GCS-100 Induces Cancer Cell Death By Mechanism Similar To Approved Chemotherapies - BusWire

• High-dose radioimmunotherapy (Bexxar) versus conventional high-dose therapy and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin's lymphoma: a multivariable cohort analysis. Blood. 2003 May 15 PMID: 12750161 - PubMed

• New Therapeutic Strategies in Chronic Lymphocytic Leukemia (CLL) - MDACC Vol. 8, No. 2, Spring 2003 

• Emerging Immunotherapies for Non-Hodgkin Lymphomas: The Tortoise Approaches the Finish Line -  Oliver W. Press, MD, PhD - annals.org

• FDA Approves Velcade (PS-341) for Multiple Myeloma Treatment - FDA.gov 5_13_03 -- The FDA today announced the approval of Velcade (bortezomib) injection, a new treatment for multiple myeloma, a cancer of the bone marrow. FDA reviewed the application for this drug in less than four months. Velcade is the first in a new class of anticancer agents known as proteasome inhibitors.

• Ethics of clinical trials from a bayesian and decision analytic perspective:
  whose equipoise is it anyway? - BMJ 2003;326:980-981

• Future of Monoclonal Antibodies in the Treatment of Hematologic Malignancies -  Medscape (free login req.)

• Picture A Cure: Putting A Face On Cancer - ACS Advocacy Action
  "what if you could combine the ease of writing a letter with the impact of meeting face-to-face? You can through our advocacy tool “Picture A Cure.”

• Would a clinical trial be appropriate for me? Questions for your doctor.  A free printable brochure prepared by Patients Against Lymphoma - PDF | PDF-Help

• Harmonizing Research and Treatment Goals - Lymphomation.org

• Doctors aim to end conflicts of interest - Cancer specialists issue new guidelines - Houston Chronical 4_03

• Anti-CD40 monoclonal antibody therapy in combination with irradiation results in a CD8 T-cell-dependent immunity to B-cell lymphoma.
  Blood. 2003 Apr 24 [epub ahead of print] PMID: 12714523 - PubMed

• Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area. Cancer. 2003 May 1;97(9):2236-41.
  PMID: 12712477 - PubMed

• Technique Brings Immune-Based Therapies Closer To Reality -  hopkinsmedicine.org "... inexpensive, reliable way to make large quantities of targeted immune cells" 

• Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Leukemia. 2003 Apr;17(4):746-50. PMID: 12682632 - PubMed

• Gene profiling shows promise in diagnosis of cancer - sunspot.net

• New Patient Privacy Rules HIPAA (Health Insurance Portability and Accountability Act) -  Details from HHS  | Perspectives from Boston Globe

• HCV (hepatitis C virus) Infection Linked to Non-Hodgkin's Lymphoma Risk in U.S. - Medscape (free login req.) Apr_03

• Review of :"Long-term remission in mantle-cell lymphoma following high-dose sequential chemotherapy and in vivo rituxan-purged stem cell autografting (R-HDS regimen)" Blood - Docguide.com 4_4_03

• Rituximab plus chemotherapy in follicular and mantle cell lymphomas.
  Semin Oncol. 2003 Feb;30(1 Suppl 2):16-20. Review. PMID: 12652460 - PubMed

• Variation in gene expression patterns in follicular lymphoma and the response to rituximab. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1926-30. PMID: 12571354 - PubMed

• Getting a Second Opinion > James Armitage, MD - CureToday.com

• 4-year data: Safety of Yttrium-90 Ibritumomab Tiuxetan Radioimmunotherapy for Relapsed Low-Grade, Follicular, or Transformed Non-Hodgkin's Lymphoma. J Clin Oncol. 2003 Apr 1;21(7):1263-70. PMID: 12663713 - PubMed

• FDA Approves New Drug to Combat Nausea and Vomiting for Cancer Patients Getting Chemotherapy - FDA 03_26_02

• The immune system: a target for functional foods? Br J Nutr. 2002 Nov;88 Suppl 2:S165-77. Review. PMID: 12495459 - PubMed

• Preparative regimens of thymoglobulin beneficial for marrow transplant
  patients - Preparative regimen found to reduce risk of acute and chronic GVHD. - hemonctoday.com  03_03

• Making sure the chemo isn't worse than the cancer - Doctors seek a way to customize treatment for each patient - seattlepi.com
  "How you metabolize (the drug) is a clear predictor of whether you are in the 10 to 15 percent of people with organ damage"  

• Nonmyeloablative (mini) Allogeneic Stem-Cell Transplantation for Hematologic Malignancies: A Systematic Review from Cancer Control: Journal of the Moffitt Cancer Center - Medscape (free login req.) 3_5_03

• Old drugs bring new cancer hope 03_11_03 - Health Newswire
  "Two drugs [clofibric acid, and medroxyprogesterone acetate] have been found to kill cancer cells, which could lead to a breakthrough in the treatment of a particularly aggressive form of blood cancer [Burkitt's lymphoma], according to UK researchers."

• Public Attitudes Toward Participation in Cancer Clinical Trials 
  Robert L. Comis, Jon D. Miller, Carolyn R. Aldigé, Linda Krebs, Ellen Stoval - jco.org  Journal of Clinical Oncology, Vol 21, Issue 5 (March), 2003 
  "Conclusion: ...  the primary problem with accrual is not the attitudes of patients, but rather that the loss of potential participants is the result of the unavailability of an appropriate clinical trial and the disqualification of large numbers of patients. The pool of willing patients is further reduced by the reluctance of some physicians to engage in accrual. "

• FDA toughens stance on Canadian imports - ReutersNew 03_13_03

• Ricin cancer therapy to be tested to treat lymphoma - BBC News 3_11_03

• Organically Grown Foods Higher In Cancer-fighting Chemicals Than Conventionally Grown Foods - American Chemical Society 3_04_03

• Neuroprotective effect of vitamin e supplementation in patients treated with Cisplatin chemotherapy. J Clin Oncol. 2003 Mar 1;21(5):927-31. PMID: 12610195 - PubMed

• Treatment-Related Myelodysplasia and Acute Leukemia in Non-Hodgkin's Lymphoma Patients. J Clin Oncol. 2003 Mar 1;21(5):897-906.
  PMID: 12610191 - PubMed 

• Treatment of cutaneous T cell lymphoma: current status and future directions. Am J Clin Dermatol. 2002;3(3):193-215. Review.  PMID: 11978140 - PubMed | Reader-friendly

• Radiation link to cancer explained - BBC 2_27_03

• Drug response linked to genes in lymphoma patients - GNN 2_21_03
  "The researchers identified about 150 genes in lymph tumors that could help predict the drug response. The activity of these genes differed significantly between patients who responded to treatment and those who did not. "

• Antineoplastons - Burzynski - The Cancer Letter review

• Trans fat lurks in a multitude of foods. It’s not labeled. And it’s bad for your heart. Here’s how to avoid it.  - ComsumerReports.org 02_23_03

• Cancer in the Home: - Healthology at Lymphomation.org
  A "New Normal" Part One Interview with Dr. Wendy Harpham

• Cancer in the Home: - Healthology at Lymphomation.org
  Recurring Hope, Part Two Interview with Dr. Wendy Harpham

• Toxic neuropathy in patients with pre-existing neuropathy.
  Neurology. 2003 Jan 28;60(2):337-40. PMID: 12552058 - PubMed

• Study finds fruit reduces risk of cancer - The Guardian 02_20_03

• Lack of serological evidence for an association between simian virus 40 and lymphoma. Int J Cancer. 2003 Apr 10;104(4):522-4. PMID: 12584752 - PubMed / Serology - A blood test that detects the presence of antibodies to a particular antigen

• Complete remission of tumour with interleukin 2 therapy in a patient with non-Hodgkin's lymphoma post allogeneic bone marrow transplant associated with polyclonal T-cell bone marrow lymphocytosis.
  Br J Haematol. 2003 Feb;120(3):523-525. PMID: 12580972 - PubMed

• Rituximab plus CHOP (R-CHOP) overcomes bcl-2-associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL). Blood. 2003 Feb 6 PMID: 12576316 - PubMed

• Record Number of Cancer Cases Predicted - HealthScoutNews 02_12_03

• Transplant May Help Incurable Lymphomas - Less Toxic Treatment Appears to Cure Some Patients - ACS 01_22_03

• Pre-clinical testing HuMax-CD20 appears to kill tumor cells resistant to rituximab - Genmab (drug sponsor)  

• CHOP: Dose Intensive and Dose Dense CHOP Regimens - Abstracts & Commentary - CTCLconsult.com 02_01_03
  "Even if these dose-dense or intense regimens were to show some advantage they would not be appropriate for a large proportion of patients who are either older or have significant comorbid illness."

• A User’s Manual For The IOM’s ‘Quality Chasm’ Report PDF |  PDF-Help
  "the Quality Chasm report has attracted much less public attention than "To Err Is Human" did, but for the serious student of health care quality and the serious leader of needed change, it signals the possible dawning of a new and persistent sense that the U.S. health care system’s performance in many dimensions, not just safety, is unacceptably far from what it should be."

• BCL-2 Expression Predicts Poor Outcome in Classical Hodgkin's Disease - Will Boggs, MD - Medscape (free login req.) 02_01_03

• Thalidomide-Like Drug Has Potential to Fight Cancer - ReutersNew 02_03_03

• Radiotherapy blow to fertility underestimated Eggs twice as sensitive to cancer-treating radiation.  - Nature.com 01_31_03

• Regimen Tailored to Elderly Patients Shows Promise Against NHL - Medscape (free login req.) 02_01_03

• Irinotecan in Relapsed or Refractory Non-Hodgkin’s Lymphomas, Vol 16, No 8, Suppl 7 (August 2002) - cancernetwork.com

• Drug Sales Bring Profits, and Scrutiny, to Cancer Doctors - NYTimes 01_26_03 (free login req.) 

• Shared decision making - Who Decides? But the answer is not so obvious anymore; it is confounded by other questions: Whose preferences matter more? In situations of uncertainty about the best way to manage a given condition, whose preferences should prevail? Are more care, more intervention, more hospitalization and more screening better than less? - James N. Weinstein, DO, MS AAOS

• Well-Informed Patients Consider Joining Clinical Trials 
  Physicians Should Seek to Explain Benefits Whenever Possible ACS 8_29_01
  If more physicians worked to increase their patients’ awareness about the value of clinical trials, participation might increase and help advance treatments for cancer, according to new research on patient attitudes about such studies, published in the August Journal of Clinical Oncology (Vol. 19, No. 15: 3554-3561).

• Report Supports Association Between Agent Orange and CLL 
  "A re-evaluation of evidence now supports an association between exposure to herbicides used during the Vietnam War and the development of a specific form of leukemia in veterans" - IOM - nationalacademies.org

• Too much vitamin A boosts risk of broken bones - ReutersNew 1_22_03

• Two-weekly CHOP with G-CSF: New Standard Regimens for Elderly Patients with Aggressive Non-Hodgkin's Lymphoma - mednet.ca
  
  "Finally, it appears that improvements on CHOP21 for the elderly are
  emerging from different directions. One approach involves the delivery of
  CHOP cycles over the shorter period of 14 days with granulocyte-colony
  stimulating factor (G-CSF) support (CHOP14G), while the other adds the
  anti-CD20 monoclonal antibody rituximab to CHOP21 (R-CHOP21)."

• Prolonged single-agent versus combination chemotherapy in indolent follicular lymphomas: a study of the cancer and leukemia group B.
  J Clin Oncol. 2003 Jan 1;21(1):5-15. PMID: 12506163 - PubMed

• Review Notes Medical Research Conflicts - abcnews  1_21_03

• Measuring health-related quality of life in clinical trials that evaluate the role of chemotherapy in cancer treatment,  Michael Michael, MB, BS; Ian F. Tannock MD, PhD  -  CMAJ

• France Boosts Campaign Against Cancer - ReutersNew 1_17_03

• Canadian Federal government derelict in fighting cancer: group - CBC 1_17_03

• Man turns to tobacco to cure cancer - Los Angeles Times  Jan_07_03

• Gene (HGAL) identified that strongly predicts survival in diffuse large B-cell lymphoma. Blood 2003; 101: 433-40.. - PubMed

• Reovirus Therapy Demonstrates Activity Against Lymphoid Malignancies - Medscape (free login req.) 01_07_03

• Biotech Survives Its Toughest Year Ever - PRNewswire 01_03