acute lymphocytic 
leukemia (ALL)

Also see Childhood Lymphoma

B-cell stage: stem cell

Return to top 

"ALL is the most common cancer occurring in children, representing 23% of cancer diagnoses among children younger than 15 years of age and occurring at an annual rate of approximately 31 per million. There are approximately 2,400 children and adolescents younger than 20 years of age diagnosed with ALL each year in the United States.

There is a sharp peak in ALL incidence among children ages 2 to 3 years (> 80 per million per year), with rates decreasing to 20 per million for ages 8 to 10 years." - NCI 2002 [1]

1. Childhood Acute Lymphoblastic Leukemia- NCI  - for Health Professionals
   Important: review links at the bottom of the NCI site for studies related to treatment.

AIDS / HIV - Related Lymphoma

Return to top

Burkitt's

Also see:
Childhood Burkitt's Lymphoma

Return to top

Lymphomatoid 
papulosis (LyP)

has been described as a "self-healing" lymphoma

Return to top

"Lymphomatoid papulosis (LyP; Macaulay disease) is a chronic lymphoproliferative (lymphocytes dividing and expanding rapidly) disease of the skin characterized by recurrent crops of pruritic (itching) papules that may ulcerate. The papules heal spontaneously over a period of 1-2 months, usually leaving slightly depressed oval scars."  e-medicine

Lymphoid granulomatosi

Return to top

"Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin." [3] which is frequently associated with Epstein-Barr virus infection. [4]

"The pathogenesis of LYG is unknown; however, recent studies have provided overwhelming evidence that LYG is a distinctive type of malignant lymphoma associated with immunosuppression."  e-medicine

1. About   e-medicine 

2. Successful treatment of mediastinal lymphomatoid granulomatosis with rituximab monotherapy. Eur J Haematol. 2005 Mar;74(3):263-6. PMID: 15693798 | Related articles

3. Fatal haemoptysis in a case of lymphomatoid granulomatosis treated with rituximab.
   Eur Respir J. 2006 Mar;27(3):644-6. PMID: 16507866

4. [Efficacy of rituximab in lymphomatoid granulomatosis] Rev Mal Respir. 2004 Dec;21(6 Pt 1):1157-61. French. PMID: 15767962 | Related articles

5. Pulmonary lymphomatoid granulomatosis. Evidence for a proliferation of Epstein-Barr virus infected B-lymphocytes with a prominent T-cell component and vasculitis.
   Am J Surg Pathol. 1994 Aug;18(8):753-64. PMID: 8037289
   

Splenic Lymphoma with Villous Lymphocytes

B-cell stage: mature, before antigen exposure

Associated with
hepatitis C virus

Often misdiagnosed as CLL

Return to top

"Splenic lymphoma with villous lymphocytes (SLVL) is a recently recognized entity among chronic B lymphoproliferative disorders. It has a distinct clinical, morphological and immunophenotypic pattern and was previously described under a variety of designations. SLVL can be misdiagnosed as chronic lymphocytic leukemia (CLL), prolymphocytic leukemia (PLL), or hairy cell leukemia (HCL)."  kfshrc.edu.sa

Also see: Marginal Zone - Splenic

Waldeyer's ring lymphomas

Return to top

We analyzed data from a population based NHL registry on patterns of dissemination at diagnosis, response to treatment, patterns of failure and survival of 77 primary Waldeyer's ring Non-Hodgkin's lymphomas (WR NHL) patents. Data of completely staged patients with diffuse large cell lymphomas (DLCL) originating in WR (n=44) were compared with those of patients retrieved from the same registry with DLCL originating in lymph nodes or stomach (the latter as prototype of a lymphoma originating in MALT). 

Primary WR NHL had favorable risk scores according to the International Prognostic Index (IPI), and responded well to therapy: a complete response (CR) rate of 74% was observed. 

Disease free survival (DFS) and overall survival (OS) were poor, however (47% and 31% at 10 years, respectively). The comparison of DLCL originating in WR, lymph nodes and stomach revealed that WR and gastric NHL patients shared a restricted pattern of dissemination at diagnosis, in contrast to patients with DLCL originating in lymph nodes." ¹

1. Waldeyer's ring lymphomas: a clinical study from the Comprehensive Cancer Center West population based NHL registry. Leuk Lymphoma. 2001 Sep-Oct;42(5):1005-13.
   PMID: 11697617

2. Waldeyer's ring lymphomas: the prognostic factors and the treatment outcome Year: 2002 Abstract No: 1138

 Post Transplant Lymphoproliferative Disorder (PTLD) 

Return to top

They have been divided into several general pathologic categories that have prognostic [outcome] significance. These include early or hyperplastic PTLD, polymorphic PTLD, and lymphomatous or monomorphic PTLD. 

The majority of PTLDs are of B-cell origin and contain Epstein-Barr virus (EBV). However, PTLDs of T- or NK-cell origin have been described, and late-arising EBV-negative lymphoid tumors are becoming more frequently reported in this population." ³

1. Discovery of mechanism that may explain post-transplant lymphoproliferative disorder  newsmedicinenet

2. Post-transplant lymphoproliferative disorder is the most common malignancy, with the exception of skin cancer, after solid organ transplantation in adults. The incidence varies according to the transplanted organ and is often associated with Epstein-Barr virus. Prognosis is variable, due in part to the heterogeneity of the disease, which ranges from reactive plasmacytic hyperplasia to aggressive monoclonal disease.  oncologist

3. The diverse pathology of post-transplant lymphoproliferative disorders: the importance of a standardized approach. Transpl Infect Dis. 2001 Jun;3(2):88-96. Review. 
   PMID: 11395974

 Other lymphomas

Return to top