Bone Marrow Transplantation (BMT) and Peripheral Blood Stem Cell (PBS) Transplantation: 
Questions and Answers - cancer.gov 
 1)  What are bone marrow and hematopoietic stem cells?  Cancer.gov
 2)  What are bone marrow transplantation and peripheral blood stem cell transplantation? Cancer.gov
 3)  Why are transplants used in cancer treatment?  Cancer.gov 
 4)  What types of cancer are treated? Cancer.gov 
 5)  How are the donor’s stem cells matched to the patient’s stem cells in allogeneic or syngeneic transplantation? Cancer.gov
 6)  How is bone marrow obtained for transplantation? Cancer.gov  
 7)  How are peripheral blood stem cells (PBSCs) obtained for transplantation? Cancer.gov 
 8)  How are umbilical cord stem cells obtained for transplantation? Cancer.gov 
 9) Are any risks associated with donating bone marrow? Cancer.gov 
10) Are any risks associated with donating PBSCs? Cancer.gov
11) How does the patient receive the stem cells during the transplant?  Cancer.gov 
12) Are any special measures taken when the cancer patient is also the donor (autologous transplant)? Cancer.gov 
13) What happens after the stem cells have been transplanted to the patient?  Cancer.gov 
14) What are the possible side effects of BMT and PBSCT? Cancer.gov 
15) What is a “mini-transplant”?  Cancer.gov 
16) What is a “tandem transplant”?  Cancer.gov
17) How do patients cover the cost of BMT or PBSCT? Cancer.gov 
18) What are the costs of donating bone marrow, PBSCs, or umbilical cord blood? Cancer.gov 
19) Where can people get more information about potential donors and transplant centers?  Cancer.gov

Cord blood banking, and overview: cancer.umn.edu/ 

Modified Bone Marrow Cells Engraft More Efficiently ~ Karla Gale - Medscape (free login req.)

Cord Blood Banking for Potential Future Transplantation: Subject Review AMERICAN ACADEMY OF PEDIATRICS Work Group on Cord Blood Banking - Recommendations aap.org 

Cord Blood Transplant Resources - GrannyBarb & Art's

Re-immunization after SCT

Clinical outcome: StemEx to expand cord blood-derived stem cells

Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial  nature.com/bmt

One limitation of cord blood-derived stem cells is insufficient quantity of  stem cells from this source. This clinical study applied a new technology  (use of StemEx to expand the number of stem cells (cd34+)) with the goal of  making SCT feasible for people without a matched donor.

Trial of Interest: 

StemEx® Expanded Stem Cells Derived from Cord Blood to Treat Subjects With High Risk Hematologic Malignancies, Following Myeloablative Therapy (ExCell) 

Conditions: 
    NHL with induction failure or relapse and sensitive to last chemotherapy course, and
    MDS with intermediate 2- or high-risk IPSS score. 

Rationale and goal:  The purpose of this study is to determine the efficacy and safety of transplanting StemEx® in patients with certain hematological malignancies. For these patients, it is suggested that StemEx® can improve upon the outcome of transplanting a single, un-manipulated cord blood unit by significantly increasing the number of stem/progenitor cells available to the patient.. 

Clinical Need: Only 30% of patients who could benefit from this procedure have an HLA-matched sibling. The lengthy search for a matched donor may critically delay transplantation. In addition, far fewer patients of racial minorities find suitable HLA-matched donors. Umbilical cord blood (UCB) has been increasingly used as an alternative source of stem cells; however, its use in adults and adolescent patients is limited due to insufficient cell dose required for satisfactory hematopoietic reconstitution.

Sponsor's website: http://stemexstudy.com/  

 
TOPIC SEARCH Cord blood derived Stem Cell transplantation - PubMed

Comparable results of umbilical cord blood and HLA matched sibling donor hematopoietic stem cell transplant after reduced-intensity preparative regimen for advanced hodgkin's lymphoma.
Blood. 2005 Dec 29; PMID: 16384924

Stem cells derived from the umbilical cords of newborn babies are a viable and effective transplant source for thousands of leukemia patients who have no other treatment option ~ EurekaAlert.org Nov 2004