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Advocacy and Notices | Collaborations / Systems | Clinical Trials | Food for Thought  | Outcome Reports
PAL Updates | Survivorship | Technical | Videos / Webcasts

Recent News and Archived News below

Survivorship and Support
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Insurance - KevinMD: The problem of insurance gaps in cancer patients
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Financial - Cure: Resources to Ease the Financial Burden of Cancer
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Living - Psych Central: 9 Ways to Take Care of Yourself When You Have Depression
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Living - MDA: Letting People Know (you have cancer)
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Living - ESMO: Anxiety and Depression in Cancer patients

An excellent presentation on anxiety and depression in cancer patients. Audio would not load, but can go through slides. Talks about cancers that can present with depression (lymphoma is one of them) and medications that can cause symptoms
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Teamwork - CLL topics Update: Controversies in Communication
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Teamwork - Kevin MD: Doctors who give cash to patients for running late
Outcome Reports
2011 ASH abstracts
Sorted by agent or indication:
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DLBCL - Cancer: Limited-stage diffuse large B-cell lymphoma treated with abbreviated systemic therapy and different types of consolidation radiotherapy
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FL - expert perspective - Medscape, Dr. Cheson: Reason to RESORT to Rituximab Maintenance?
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Hodgkin - expert Perspective - Medscape, Dr. Cheson: Radiation Therapy vs Chemo in Hodgkin Lymphoma Patients
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Hodgkin - ASCO: Favorable Early-stage Hodgkin Lymphoma and HD.6: The Take-Home and Don’t–Take-Home Messages
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RIT - expert perspective - Medscape, Dr. Cheson: Radioimmunotherapy: How Strong an Option Is It?
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MZL, nodal, review article - CancerNetwork.com: Nodal Marginal Zone B-Cell Lymphoma: A Diagnostic and Therapeutic Dilemma
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SCT - Annals of Hematology: Allogeneic stem cell transplantation in patients with DLBCL relapsed after autologous stem cell transplantation
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T-cell - Univ Hospitals Case Medical Ctr: UH Case Medical Center publishes study on novel treatment for Cutaneous T-Cell lymphoma 

"By adding O6-benzylguanine, we can effectively lower the dosage of the topical treatment, carmustine, and render it less toxic on healthy cells but more effective at killing cancer cells," says Dr. Cooper. "This combination treatment has had excellent initial clinical results and we are following it up with additional ongoing studies."

Related Study of Interest - O6-Benzylguanine and Topical Carmustine in Early-Stage (IA-IIA) Cutaneous T-Cell Lymphoma:
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Transformed lymphoma - BJH (correspondence): Improving survival in patients with transformed B cell non Hodgkin lymphoma: consolidation with Zevalin-BEAM and autologous stem cell transplantation
Technical / Theory / Preclinical / Associations
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News Medical: Study investigates immune response in cancer
Videos / Webcasts
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PBS: Cancer Treatment: Are Personalized Molecular Profiles in Our Future?
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Patient Power: Physician Turned Patient: My Quest for the Best CLL Treatment
Advocacy and Notices
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Advocacy, expert perspective - Medscape: Clinical Trial Woes: Dr. Bruce Cheson on Where Are the Drugs?
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The Columbus Dispatch: Cancer drugs should be treated equally

“It’s disturbing to think that this inequity in coverage [for oral versus IV administered drugs] may keep patients from receiving the most-effective treatment available for their cancer.”
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June - International Waldenstrom's Foundation: Mark your calendars for the IWMF Ed Forum in Philadelphia, PA from June 1 to June 3!
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Healthcare reform articles
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MSNBC: Drug Shortages hits all time high
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Drug Shortages CRISIS and How to address!
With reports on causes
Collaboration / Systems
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Be The Match - Patients Connect Facebook Page

People can join the Be The Match Registry® – the world’s largest listing of potential marrow donors and donated cord blood units – contribute financially and volunteer.

Clinical Trials of Interest / Tools
 

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Cutaneous t-cell lymphoma, Study of Interest
 - O6-Benzylguanine and Topical Carmustine in Early-Stage (IA-IIA) Cutaneous T-Cell Lymphoma:  
Tools:
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Find trials by 
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Type of Agent (New agent added)
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By Type of Lymphoma & Treatment Status
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Trials of interest  (seeking comment)
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New Trials
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7 Reasons to Consider Trials:
based on your clinical circumstances
Food for Thought / Evaluating Evidence

See also PAL on this topic
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Acupuncture - J Altern Complement Med. 2008 - The Status and Future of Acupuncture Clinical Research
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Second Pathology Evaluations: WSJ: Informed Patient: Diagnostic Errors Highlight Need for Second Opinions
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CAM - Is there any merit in the concept that to restore health you have to "Alkalinize your blood  to fight cancer?

Respectful Insolence: Acid Base or Woo

Respectful Insolence: Acid Base or Woo, revisited
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CLL Topics Updates: How to Treat Elderly CLL Patients
PAL Updates
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Archive: Links to interesting slide on lymphoma
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Caregiver tips
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Trials of interest
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Getting a Second Pathology Evaluation
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Lymphoma in the Elderly
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New Year Musings on Progress Against Lymphoma
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Help PAL by donating a vehicle - running or not! 

 

Special Thanks is Due to Anjou!

 

Recent News and Archived News below

Recent News

Se also Brand New  and Archived

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Cure: Why Banks Need Your Tissue for Research
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Alt Med - Sloane Kettering: Complementary vs. Alternative Cancer Therapies
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BoingBoing: Three common mistakes in medical journalism
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Causes of cancer - Cure Today: Connecting the Dots: Why It's So Hard to Pin Down Environmental Causes of Cancer
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Resveratrol - In the Pipeline: A Resveratrol Research Scandal. Oh, Joy
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allo SCT - Perspective - Current role of allogeneic stem cell transplantation in follicular lymphoma
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Zevalin - Cancer: Myeloablative doses of yttrium-90-ibritumomab tiuxetan and the risk of secondary myelodysplasia/acute myelogenous leukemia.

snip: "incidence of sMDS/AML, which nevertheless was comparable to the incidence observed in a matched group of patients who received chemotherapy-based conditioning.”
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Sustainability - NYTimes: It Costs More, but Is It Worth More?

snip: “So a second option is “coverage with evidence development.” In this approach, Medicare would pay for proton beam treatment … only if the patients were enrolled in a randomized trial that would compare the outcomes of their treatment to those from surgery, other kinds of radiation or active surveillance. Medicare has used this approach sparingly, but it should be applied to more cases like this one.”
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Celebrities with lymphoma - Reuters: Black Sabbath guitarist diagnosed with lymphoma
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End of Life - Denialism Blog: How Do you Want to Die?

Speaks frankly about end of life issues, if reading about these issues upsets you please don't open.

Also: How Doctors Die
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Family Practice News: Pregnant Women With Lymphoma Can Have Good Outcomes
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Fertility - Springer: Cancer and fertility -- young women speak up
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Nutrition - ACS: Updated American Cancer Society nutrition guidelines stress need for supportive environment
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Nutrition - Oncology Times: ACS Updates Nutrition and Physical Activity Guidelines

snip: “The guidelines are really about educating people about what they can do on their own to reduce the risk of cancer, but are also designed to spur action for change -- to make it easier for people to get a banana instead of a candy bar,”
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Teamwork - NYTimes: Project Puts Records in the Patients’ Hands
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Teamwork - MDA: Advance Care Planning: A Patient and Provider Partnership
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Hodgkin- Patient Power: Expanding New Treatment Option to Frontline Treatment for Hodgkin Lymphoma
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Hodgkin- The Oncology Report: New Scoring System Devised for Youth With Hodgkin's Lymphoma
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SCT - Patient Power: Keeping Transplant Patients Safe: Behind the Scenes with an Infectious Disease Specialist
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Patient Power: Fighting Cancer in Your 20s: Lessons Learned

Rose Egge never thought she would be facing a cancer diagnosis at 25 years  old. ... Now, Rose helps other young adults cope with a cancer diagnosis through her foundation, Thrive Through Cancer.
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MCL - LLS November 2, 2011 - Mantle Cell Lymphoma

archived video and transplant for those who may have missed the presentation
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MCL - Blood: Comparative outcome of initial therapy for younger patients with mantle cell lymphoma: an analysis from the NCCN NHL Database.

Author's comment: "Future trials should focus on novel agents rather than comparing efficacy of current approaches."
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Cancer biology - Johns Hopkins: Cancer Cells feed on Sugar-free diet
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Walter and Eliza Hall Institute: Research shows cells influence their own destiny
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Blood - Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia

Targeting the microenvironment could improve sensitivity to treatment. 
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Fertility - Patient Power: Oncofertility: Fertility Preservation for Cancer Patients
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CLL - Patient Power: Dr. Steven Rosen on Breakthroughs in Chronic Lymphocytic Leukemia from ASH 2011
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Hodgkin - Patient Power: Dr. Ajay Gopal on Robust Treatment Options Keep Hope Alive
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Elderly - Cancer Chemo and Pharmacology: Addition of rituximab to reduced-dose CHOP chemotherapy is feasible for elderly patients with diffuse large B-cell lymphoma
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HCV Infection and Cryoglobulinemia
Antiviral Therapy in HCV-Positive NHL: Pathogenetic Implications 

A systematic review of subsequent studies reported that 75% of HCV-infected patients with B-NHL treated with pegylated interferon-α (pIFN-α) plus ribavirin (RBV) achieved a complete hematological response (CHR), whereas no such response was obtained in matched HCV-uninfected B-NHL patients. Our own experience refers to a retrospective analysis ...”

See also
MJH, 2010:
Hepatitis C Virus Infection and Lymphoma
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Histone Deacetylase (HDAC) Inhibitors: Potential in Cancer Therapy
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Hodgkin: PubMed: PET/CT surveillance in patients with Hodgkin lymphoma in first remission is associated with low positive predictive value and high costs.
 
Full text: haematologica.org
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SCT - AM J Hematology: Autologous stem cell transplant is feasible in very elderly patients with lymphoma and limited comorbidities
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Allo SCT - Biol Blood Marrow Transplant. 2011 - HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation.

HLA-C antigen-mismatched unrelated PBSC donors were associated with worse outcomes compared with 8/8 HLA-matched donors. 
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T-cell: Pubmed: Efficacy and safety of the third-generation Fotemustine for the treatment of chemo-refractory T-cell lymphomas.
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Science Based Medicine: Why Do We Really Need Clinical Trials?

"Given the incredible number of complex, interacting factors involved in the development of each particular disease, it shouldn’t surprise us when even a reasonable hypothesis with limited support from observational trials and other lower level evidence turns out to be false."
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Medscape (login required): Dr. Cheson - Great New Drugs Will Be Harder to Come By

"So, it's sort of a conundrum. The more effective regimens we develop, the higher the bar, and the more difficult it is for new drugs to come down the pike."
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ASH review  - Cheson and Leonard - Medscape:
Has Rituximab Met Its Match in Lymphoma ... and other topics?
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Preclinical models - NPR: Perhaps Scientists Like Lab Mice TOO Much
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CLL Topics Update: "Doc, how long do I have" Discusses prognostic factors in CLL
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General Health - US Preventative Service Task Force: Vitamin D With or Without Calcium Supplementation for Prevention of Cancer and Fractures An Updated Meta-Analysis

“ Evidence is not sufficiently robust to draw conclusions regarding the benefits or harms of vitamin D supplementation for the prevention of cancer.”
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Living - Cancer Connect: Showing Love in the Face of Loss  

the peaks and valleys of my emotions eventually started to level out somewhat. When my child’s birthday or Christmas arrived, I had to brace myself and just concentrate on breathing.
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Living - Crazy Sexy Cancer: 10 Things I Learned from People Who Survive Cancer
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Living - Psych Central: When Cancer Patients also grapple with depression
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Medical Errors - KevinMD.com How patients can avoid medical errors
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Prevention - MDA: Diet and Cancer  

... diet is thought to account for about 30% of cancers in Western countries.
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Safety - Science Based Medicine: Reducing the Risk of Adverse Drug Events

“The elderly are seven times as likely as younger people to have adverse drug events. ... Forty percent of people over 65 take 5-9 medications, and 18% take 10 or more. Combinations of medications can cause unexpected problems.”
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Financial - Cure: Medical Debt: An Unspoken Side Effect of Cancer Care
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CLL - Medscape (login required):
New Class of Drug May Vanquish CLL

Also see Navitoclax - Lancet, Wilson et al a Targeted High Affinity Inhibitor of BCL-2 (ABT-263), in Lymphoid Malignancies - full text
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CLL - Patient Power: Dr. Steven Rosen on Breakthroughs in Chronic Lymphocytic Leukemia from ASH 2011
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Hodgkin - Patient Power: Dr. Ajay Gopal on Robust Treatment Options Keep Hope Alive
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MZL - ASH 2011: Patients with Limited Stage Extranodal Marginal Zone Lymphoma Have Excellent Survival regardless of Choice of Therapy Type or Observation
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T-cell, cutaneous - PubMed: Photodynamic Therapy with methyl-aminolaevulinic acid (MAL) for Mycosis Fungoides
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Caregivers - Oncology Times: Gender Differences Can Make a Difference in Caregiving

“Overall, the belief is that women facing a crisis find comfort in discussing their fears, while men take solace in action.”
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Disparities - Cancer: Survival disparities by Medicaid status An analysis of 8 cancers
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General Health - NY Times: The Fat Trap

There have been studies that suggest obesity may raise risk for lymphoma and other cancers. Excellent article on why it's difficult to maintain weight loss
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Skin care - The Examiner: Tips for skin care during cancer treatments
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News Medical: Scientists discover a way to keep normal and cancer cells alive in the lab
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Weill Cornell, Dr. Martin: Obinutuzumab (GA101), a New Generation Rituximab
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CLL: Patient Power: Update on Kinase Inhibitors for CLL: Where Are We Now?
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NPR: The War on Cancer turns 40
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NPR: If it’s not a war on cancer, what is it? 
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CLL Topics: A Well Designed PCI-32765 Clinical Trial – just about to open
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Dr. Len's Cancer Blog: We Can Find You A Space In The Mall Parking Lot, Ma'am, But Your CT Scan Will Have To Wait
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Hodgkin - Cure: Brighter Horizons for Hodgkin Lymphoma Patients

More ... Archive

 

 
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For all medical concerns,  you should always consult your doctor. 
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