| |||||||||
______________________________________________________________________________________
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Approximately 500,000 people in the United States are living with Lymphoma. | |
|
Lymphoma is the most commonly occurring blood cancer, and is the third most common childhood cancer. | |
Generally,
the shorter the survival the lower the prevalence in relation to
incidence. For lymphoma the ratio of incidence (61,000) to
prevalence (500,000) indicates that treatment is effective |
|
Each year,
approximately 27,600 deaths are attributed to lymphoma. | |
Each day,
approximately 75 people die of the lymphoma. | |
|
The five-year relative survival rate for
non-Hodgkin's lymphoma patients has |
|
Approximately 45% of patients with
aggressive non-Hodgkin’s lymphomas can be cured with standard
treatments, | |
Approximately 50% of patients with stage I indolent follicular lymphoma, and one quarter with stage II disease, can be cured with radiotherapy. | |
|
We have calculated that approximately 37% of Lymphomas are curable with standard therapies. | |
|
The less-common Hodgkin’s lymphoma is curable about 80% of the time. | |
* The aggressive type of NHL has a shorter natural history, but approximately 40-50% of patients can be cured with combination chemotherapy. | |
|
** Current estimates of median survival for indolent follicular lymphoma, the most common form of NHL, range from 8 to 10 years. Approximately 50% of patients with stage I indolent follicular lymphoma, and one quarter with stage II disease, can be cured with radiotherapy, but the overwhelming majority of patients are diagnosed with advanced disease. The survival for indolent lymphomas is dependant on cell type and other prognostic indicators. It will take time to determine if new treatments will improve overall survival, but there are reasons to be encouraged. |
|
Ten-year survey of incidence of infection as a cause of death in hematologic malignancies: study of 90 autopsied cases. Acta Haematol. 1995;93(1):25-30. PMID: 7725846 | Related articles | |
|
Causes of
death in children diagnosed with non-Hodgkin's lymphoma between 1974
and 1985. |
|
Race |
Men | Women | ||||||||
| NHL | HD | Leukemia | CLL | MM | NHL | HD | Leukemia | CLL | MM | |
| All races | 2.18 | 0.24 | 1.50 | 0.53 | 0.70 | 1.82 | 0.19 | 1.07 | 0.33 | 0.55 |
| White | 2.32 | 0.25 | 1.61 | 0.59 | 0.68 | 1.94 | 0.21 | 1.14 | 0.35 | 0.51 |
| Blacks | 1.25 | 0.21 | 0.87 | 0.26 | 0.97 | 1.06 | 0.15 | 0.79 | 0.20 | 0.93 |
Source: SEER CSR report 1975-2002
NOTE: For blood cancers, risk are generally higher in white men. A notable exception to the risk of Multiple myeloma in black men and women.
Comparing age-adjusted incidence rates:
Leukemias: 12.3 per 100,000 men and women per year * Lifetime risk:
Lymphomas: 22.0 per 100,000 men and women per year.*** http://seer.cancer.gov/statfacts/html/leuks.html?statfacts_page=leuks.html&x=9&y=19
** http://seer.cancer.gov/statfacts/html/lymph.html?statfacts_page=lymph.html&x=16&y=17
"It is estimated that 44,240 men and women (24,800 men and 19,440 women) will be diagnosed with and 21,790 men and women will die of leukemia in 2007"
"It is
estimated that 71,380 men and women (38,670 men and 32,710 women)
will be diagnosed with and 19,730 men and women will die of lymphoma in
2007"
NOTE: CLL is classified by SEER as a leukemia, but
many experts consider it a lymphoma.
County-based statistics - dsf.health.state.pa.us/ |
|
"The incidence rate of
non-Hodgkin’s lymphoma increased by 76% for males and 49% for females between 1975 and 1994. | |
|
The mortality rate of non-Hodgkin’s lymphoma has steadily increased for males (19%) and females (17%) over the same period." - Roswell Park Cancer
Inst. | |
|
New York State Cancer Registry
- health.state.ny.us/nysdoh |
|
"The study also found statistically significant elevations of 10 to 55% in the incidence of the following cancers on Staten Island as a whole: pharynx, colon, lung, bladder, larynx in men; and pharynx, colon, lung, breast, bladder, lymphoma in women." | |
|
New York State Cancer Registry – Staten Island (Richmond) - Health.state.ny.us/nysdoh |
For more information, see - Incidence of Lymphoma in Staten Island & New York City
"The magnitude of the human and economic costs of cancer in the United States is enormous. At current rates, invasive cancer will be diagnosed in approximately 1 of every 2 American men and 1 in 3 women in their lifetimes. Cancer afflicts 2 out of every 3 families. The annual costs of cancer are estimated at about $107 billion—37 billion for direct medical costs, $11 billion for lost productivity, and $59 billion for indirect mortality costs." ~ cancer.org pdf
SEER Fast Stats - NHL | Hodgkin's (highly recommended) | |
SEER CSR Report - seer.cancer.gov pdf | |
Search
SEER Cancer Statistics Review, 1975-2000 - SEER.cancer.gov
| |
Changing
incidence of non-Hodgkin lymphomas in the United States.
| |
Non-Hodgkin's Lymphoma: U.S. Racial/Ethnic Cancer Patterns - Cancer.gov | |
SEER NHL Statistics (Cyberfamily) - PDF | PDF-Help | |
Cancer Facts and Figures 2002-1997 - ACS | |
Cancer Incidence and Mortality - edcenter.med.cornell.edu | |
SEER, about: "The Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute is the most authoritative source of information on cancer incidence and survival in the United States." | |
SEER databases - NCI | |
Cancer Trends - Dr. Richard Klausner, Director of the NCI, 2001 | |
Statistics Definitions - SEER |
View/Download Maps for Non-Hodgkin's Lymphoma - NCI | Summary text | |
The U.S. government released its first
state-by-state report on cancer
| |
Pop-chart ~ Select Cancer type to compare mortality by States - NCI |
Blood Cancers Facts and Statistics - LLS | |
"An estimated 109,500 people in the United States will be diagnosed with leukemia, lymphoma, and myeloma this year. | |
New cases of leukemia, lymphoma, and myeloma account for 8.6 percent of the 1,268,000 new cancer cases diagnosed in the United States in 2001. | |
The total estimated number of blood-related cancers has increased only slightly for each of the past three years. | |
Every five minutes, someone in the United States learns that they have leukemia, lymphoma, or myeloma, more than 300 people a day." - LLS |
OVERALL STATE OF THE SCIENCE
Excerpt from the Report of the Leukemia, Lymphoma, and Myeloma Progress Review Group May 2001 full text"Despite advances in diagnosis and treatment and improvements in patient survival, the hematologic cancers continue to have a significant impact on the lives of Americans.
Right now, almost 700,000 Americans are living with leukemia, lymphoma, or myeloma (LLM), and an estimated 100,000 new cases occur each year.
Although mortality has declined and 5-year survival rates have increased among adults and children with certain forms of these diseases, an estimated 60,000 Americans will die of them in 2001.
For all forms of leukemia, the five-year survival rate is only 46%, for non-Hodgkin's lymphoma it is 54.2%, and for multiple myeloma it is only 28%.
Despite the significant decline in the death rate for children with leukemia, this disease still causes more deaths in children in the U.S. than any other disease.
Furthermore, the death rates for non-Hodgkin's lymphoma and multiple myeloma are increasing at a time when death rates for other cancers are dropping.
Since the 1970's, incidence rates for non-Hodgkin's lymphoma have increased dramatically, making it one of the fastest rising cancers in the United States.
The hematologic cancers strike individuals of all ages, from children to the elderly; men and women; and all races." - LLMPRG report
COMMENT & QUESTIONS:
By including both indolent and aggressive NHL we are really combining two separate conditions, particularly when survival is considered, since aggressive is curable in maybe 40% of cases. This occurred to me yesterday in noting that SEER reports that about 29% are still alive after 20 years...but which ones?? Hopefully not JUST the 40% cured with aggressive, although mathematically they must comprise a large percentage. As time goes on we should try to distinguish more clearly the considerable differences between indolent and aggressive. In fact, it's too bad that our disorder is a NON something...especially since it vastly outnumbers Hodgkin's. This takes something away from the public profile of NHL...do people want to support a "non-something"? - Robert Miller.
Q: I have been diagnosed with Lymphoma Stage 4-Do you have any statistics as to the survival rate of patients with this diagnosis?
A: There is a saying in statistics that "the Median is *not* the message." Ever so true for lymphomas (emphasis on plural) in which there are so many subtypes of the disease and of the people diagnosed with it. Factors that predict the *average* survival for pts with lymphoma include the specific diagnosis, the stage of the disease (almost everyone is diagnosed with stage 4), the age and performance level of the patient, tumor burden, high LDH levels, response to initial treatment and the duration of the initial response ...
Also, survival data is always a few seasons behind and does not take into account the impact of newer more targeted treatment approaches that are available now, and of course the new treatments to arrive soon.
View/Download Maps for Non-Hodgkin's Lymphoma - NCI | Summary text | |
Pesticides Research Report: Do Pesticides Cause Lymphoma? - LFA | |
Non-Hodgkin's Lymphoma Incidence - Lymphoma Info Net | |
Brief description of mortality figures and patterns between 1950 and 1994 - NCI | |
Mortality Graphs and Maps - NCI | |
Customized
mortality Map - NCI
|
"A disturbing trend is that the incidence and mortality rates for NHL have increased, with the incidence rate nearly doubling, since the early 1970s, then stabilizing in the last 5 years. For both forms of lymphoma, incidence and mortality rates have been higher for whites than African Americans and other ethnic groups. It is estimated that, each year, $2.6 billion* is spent in the United States on treatment for lymphoma." 1

