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Side Effect - Cardiac

  

Side Effects > Cardiac (Heart)

Last update: 04/24/2008

TOPIC SEARCH: PubMed - anthracyclines | 
PubMed - general | Medscape

Anthracyclines (such as doxorubicin) are an important component for the treatment of various lymphomas, known to have a spectrum of toxicity, particularly cardiac toxicity. Cardio toxicity is increased in the elderly and pediatric patients

The threshold of the cumulative dose of doxorubicin appeared to be low: at doses >200 mg/m2, 27% of patients had cardiac events. Elderly patients appeared to be at higher risk. The development of cardio protective strategies or alternative treatments are mandatory for aggressive NHL patients. [1]

Doxil, a liposomal version of doxorubicin, appears to eliminate or reduce cardiac toxicity according to some reports [2]

Resources

Liposomal doxorubicin (Doxil™)  PAL

References and Research News

  1. Valsartan May Prevent CHOP-Induced Cardiotoxicity  Medscape (free login req.)
  2. Nad(p)h oxidase and MRP genetic polymorphisms associate with doxorubicin-induced cardiotoxicity.  ASCO 2004  Abstract No: 3021 
  3. Early cardiotoxicity of the CHOP regimen in aggressive non-Hodgkin's lymphoma. 
    Ann Oncol. 2003 Feb;14(2):277-81. PMID: 12562656 
  4. Safety and efficacy of pegylated liposomal doxorubicin (Doxil) in relapsed epithelial ovarian cancer patients: Effect of age and previous treatment. ASCO 2003 (3186)
  5. Late cardiac effects of doxorubicin therapy for acute lymphoblastic leukemia in childhood.
    N Engl J Med. 1991 Mar 21;324(12):808-15. PMID: 1997853 | Related articles
  6. Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sezary syndrome.
    Blood. 2004 Aug 1;104(3):655-8. Epub 2004 Apr 08. Review. PMID: 15073032 | Related articles
  7. Pixantrone, A New Anthracycline with Possibly Less Cardiotoxicity  cancerconsultants.com  Jan 2005
  8. Early cardiotoxicity of the CHOP regimen in aggressive non-Hodgkin's lymphoma.
    Ann Oncol. 2003 Feb;14(2):277-81. PMID: 12562656
  9. B-type natriuretic peptide (BNP) levels in patients receiving high-dose chemotherapy can detect those at risk of late cardio toxicity  medscape.com (free login req.)
  10. Patients with NHL Treated with Anthracyclines at Long-Term Risk for Chronic Heart Failure (2006)
     
    According to an article recently published in the journal Blood, patients with aggressive non-Hodgkin’s lymphoma who receive six cycles of Adriamycin® (doxorubicin) have an increased risk of cardiovascular disease. These patients should undergo long-term monitoring for cardiac conditions.  cancerconsultants.com
 
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