Here we list metabolic abnormalities in lymphoma
patients undergoing chemotherapy, and
links to resources.
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The following was adapted from: Metabolic abnormalities in
lymphoma.
Clin Lymphoma. 2002 Dec;3 Suppl 1:S32-6.
PMID: 12521387 PubMed
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Tumor lysis syndrome can result in several metabolic abnormalities, leading to potential renal failure. If these syndromes are identified promptly, they can be corrected.
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Electrolyte Imbalance, Chemocare.com
http://bit.ly/9BTMfm
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Hyperuricemia - high uric acid levels
Details: www.emedicine.com/med/topic1112.htm
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Hypercalcemia - high concentrations of calcium compounds are found in the bloodstream.
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Detailed and technical :
www.emedicine.com/EMERG/topic260.htm |
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A Practical Approach to Hypercalcemia
www.aafp.org/afp/20030501/1959.html
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Vitamin D caution |
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Question, could elevated calcium be a sign of relapse or
disease?
It seems unlikely if it's the only presenting symptom, based on
the following:
"Hypercalcemia is uncommonly associated with lymphoma
(particularly the b-cell type) but
may be seen in centres where many patients with
this disease are treated.
Hypercalcemia readily responds to
therapy and is a reversible cause of morbidity, but when
associated with lymphoma it usually indicates widespread
disease. The mechanism of hypercalcemia is unknown but there
is strong evidence for humoral factors that may or may not be
related to parathyroid hormone."
Source: Lymphoma with hypercalcemia
ncbi.nlm.nih.gov/ |
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NCI Incidence by Cancer Type
cancer.gov/
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Lymphomas |
Incidence (%)
of Hypercalcemia of Malignancy |
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Hodgkin lymphoma |
0.6–5.4 |
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Non-Hodgkin lymphoma, high-grade |
14–33 |
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T-cell lymphoma (human T-cell, lymphotrophic
virus type 1) |
50 |
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See also - PubMed Topic Search:
ncbi.nlm.nih.gov
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Hyperphosphatemia - high concentration of
phosphates in the circulating blood.
Details: www.emedicine.com/emerg/topic266.htm
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Hypocalcemia -
abnormally low calcium concentration, that can result in muscle cramps, abdominal cramps, spasms, and hyperactive deep tendon reflexes.
Details: www.emedicine.com/EMERG/topic271.htm
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Hypomagnesemia -
abnormally low levels of serum magnesium. "The primary clinical findings are neuromuscular irritability, CNS hyperexcitability, and cardiac arrhythmias."
Details: www.emedicine.com/EMERG/topic274.htm
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Hyponatremia -
abnormally low levels of serum sodium concentration.
Details: www.emedicine.com/EMERG/topic275.htm
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Hyperkalemia - a
potassium level greater than 5.5 mEq/L. Ranges are as follows: 5.5 - 6.0 mEq/L - Mild condition 6.1 - 7.0 mEq/L - Moderate condition 7.0 mEq/L and greater - Severe condition.
Details: www.emedicine.com/emerg/topic261.htm
Medicinenet
http://www.medicinenet.com/low_potassium_hypokalemia/article.htm
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