Corticosteroids,
including Prednisone, Prednisolone, Methylprednisolone and
Dexamethasone
are a group of synthetic hormones closely related to cortisol (a
glucocorticoid), a natural hormone produced in the adrenal
cortex. Sometimes referred to as steroids.
Uses:
The treatment of lymphomas and other blood cancers. It is also used to
suppress graft versus host disease, a condition that is associated with
stem cell transplant. When used in combination with
chemotherapy, steroids may enhance the killing of lymphoma cells,
and also help mitigate (reduce) fatigue, nausea, and loss of
appetite associated with chemotherapy.
Common side-effects:
Increased risk of infection, increases in blood pressure, peptic ulcers, diabetes mellitus,
osteoporosis, and depression.
What does natural cortisol
do? Manages the salt/water balance in the body,
regulates stress, regulates carbohydrates, fat, and protein
metabolism.
Mechanism related to
lymphoma treatment: Corticosteroids, and drugs that mimic them, reduce inflammation by inhibiting the production
of prostaglandins. These drugs also impede or directly reduce the
number of white blood cells by inducing apoptosis.
Possible Side Effects
Side effects depend on dose and duration. Side
effects can be minimized by following your doctor's directions and
following the prescribed dose, and weaning instructions when coming
off these powerful drugs.
