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Patients Against Lymphoma

 

Treatment Overview or Chemotherapy > Common combinations

Last update: 12/14/2013

A | B | C | D | E | F | G | H | I | J | K | L | M | N |
 O | P | Q | R | S | T | U | V | W | X | Y | Z

APO

Abstracts

==

A = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
P = Prednisolone
O = Vincristine (Oncovin®) Blocks Cell Duplication
and Methotrexate (substituted for Doxorubincin when toxicity threshold is reached.)

ATT

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==

Alternating Triple Therapy.  The protocol involves a sequence of three regimens, CHOD-Bleo, ESHAP, and NOPP.  The drugs in these regimens include:  

cyclophosphamide, doxorubicin, vincristine, belomycin, VP-16, cisplatin, mitoxantrone, procarbazine, and corticosteriods (prednisone, methylprednione, dexamethasone.) The only overlap with FND is the mitoxantrone and dexamethasone.

BEAM Mini

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B = Carmustine (BCNU®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
A = Cytarabine (Ara-C®, Cytosar®) Antimetabolites
M = Melphalan (Alkeran®) DNA-Altering

Details on BEAM: spitfire.emmes.com 

Bendamustine  Treanda 

Bendamustine
(SDX-105)

 

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B = Bendamustine (bifunctional agent with both alkylator and purine-like activity)

R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols

BEAC 

BEAC or BEAM?

 

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B = Carmustine (BCNU®) DNA-Altering
E = Etoposide (VP-16, VePesid ®) DNA Repair Enzyme Inhibitor
A = Cytarabine (Ara-C®, Cytosar®) Antimetabolites

While BEAC and BEAM appears to have equal antitumour efficacy in patients with NHL, BEAM seems to be more toxic to the gastrointestinal tract. However, randomized studies are needed for more definitive conclusions on the relative merits of various high-dose regimens in patients with NHL. PMID: 12916867

CHOP

CHOP + R

For aggressive or 
indolent lymphoma

Abstracts

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Dr. Sharman's CLL & Lymphoma Blog What is R-CHOP?

C = Cyclophosphamide (Cytoxan®) DNA-Altering
H = Doxorubicin (Adriamycin®) or Rubex® or Hydroxydaunomycin Antitumor Antibiotic
O = Vincristine (Oncovin®) Blocks Cell Duplication
P =  Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant

R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
 

CEOP-R 

CHOP-like chemotherapy

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C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin®) Blocks Cell Duplication
E = Epirubicin Epirubicin,  anthracycline drug nlm.nih.gov
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant

CODOX-M

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C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin®) Blocks Cell Duplication
D = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
M = Methotrexate (Rheumatrex®) Antitumor Antibiotic

COPBLAM

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C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin®) Blocks Cell Duplication
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
A = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
M = Procarbazine (Matulane®) DNA-Altering

CP

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C = Chlorambucil (Leukeran®) DNA-Altering
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant

CVP
 CVP + R 

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C = Cyclophosphamide (Cytoxan®) DNA-Altering
V = Vincristine (Oncovin®) Blocks Cell Duplication
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant

R = Rituxan - Monoclonal antibody against CD20 (addition of Rituxan has become standard)

CyMiR

Abstracts

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C = Cyclophosphamide (Cytoxan®) DNA-Altering
Mitoxantrone
Mitoxantrone (Novantrone®) Antitumor Antibiotic
Rituxan

DHAP

Abstracts

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D = Dexamethasone (Decadron®) steroidal: anti-inflammatory, Immunosuppressant
HA = Cytarabine (Ara-C, Cytosar®) Antimetabolites
P = Cisplatin (Platinol®) DNA-Altering

R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
 

Oxaliplatin Appears Effective (as cisplatin in DHAP & safer) in Treatment Regimen for Recurrent NHL  CancerConsultants.com 

DICE

Abstract ncbi.nlm.nih.gov

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D = Dexamethasone (Decadron®) steroidal: anti-inflammatory, Immunosuppressant
I = ifosfamide (ifek®) DNA-Altering
C = Cisplatin (Platinol®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor

R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols

EPOCH-R

Abstracts

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E = Etoposide (VP- 16, VePesid®) DNA Repair Enzyme Inhibitor
P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant
O = Vincristine (Oncovin®) Blocks Cell Duplication
C = Cyclophosphamide (Cytoxan®) DNA-Altering
H = Doxorubicin (Adriamycin®) Antitumor Antibiotic

R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols

* Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy http://bloodjournal.hematologylibrary.org/content/99/8/2685.long

EPOCH starting dose and treatment days
http://bloodjournal.hematologylibrary.org/content/99/8/2685/T1.expansion.html

How dose is adjusted
http://bloodjournal.hematologylibrary.org/content/99/8/2685/T2.expansion.html

 

ESHAP

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==

E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
S = Methylprednisolone (Medrol®) steroidal: anti-inflammatory, Immunosuppressant
HA = Cytarabine (Ara-C®, Cytosar®) Antimetabolites
P = Cisplatin(Platinol®) ) DNA-Altering

R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols
 

Alert: Severe hypomagnesaemia (low magnesium) with tetany following ESHAP protocol - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=64621 

Fludarabine

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Fludarabine (Fludara ®) Antimetabolites

Fludarabine + Rituxan

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F = Fludarabine (Fludara ®) Antimetabolites
R = Rituxan - Monoclonal antibody against CD20

FCR

Related PubMed articles: Follicular outcomes

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F= Fludarabine (Fludara ®) Antimetabolites
C = Cyclophosphamide (Cytoxan®) DNA-Altering
R = Rituxan- Monoclonal antibody against CD20

FND

FND + R
or R-FND

Abstracts

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F= Fludarabine (Fludara ®) Antimetabolites
D= Dexamethasone steroidal: anti-inflammatory, Immunosuppressant
R = Rituxan- Monoclonal antibody against CD20

Also see:

bullet Historical perspective on the treatment challenges for low-grade NHL
http://www.clinicaloptions.com/Oncology/Resources/CME%20Options/NHL.aspx  (Requires registration to listen/see presentation) 
bullet Improvement of Overall and Failure-Free Survival in Stage IV Follicular Lymphoma: 25 Years of Treatment Experience at The University of Texas M.D. Anderson Cancer Center 
http://jco.ascopubs.org/cgi/content/abstract/24/10/1582 
bullet Phase III trial of rituximab/FND in patients with Stage IV indolent lymphoma
http://www.nhlupdate.com/edition/2005/1/cabanillas.htm  

FCM+R

 

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F= Fludarabine (Fludara ®) Antimetabolites
C = Cyclophosphamide (Cytoxan®) DNA-Altering
M = Mitoxantrone ( mye-toe-ZAN-trone)  DNA intercalation; DNA topoisomerase II inhibition

R = Rituxan- Monoclonal antibody against CD20

GDP

Abstracts

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Gemcitabine, dexamethasone and cisplatin is an active and
non-toxic chemotherapy regimen in relapsed or refractory
Hodgkin’s disease: a phase II study by the National Cancer
Institute of Canada Clinical Trials Group
http://annonc.oxfordjournals.org/content/14/12/1762.full.pdf+html

[Efficacy of GDP regimen (gemcitabine, dexamethasone, and cisplatin) on relapsed or refractory aggressive non-Hodgkin's Lymphoma: a report of 24 cases].
http://www.ncbi.nlm.nih.gov/pubmed/19000458

INTERMEDIATE DOSE GEMCITABINE - CISPLATIN COMBINATION CHEMOTHERAPY (GEMCIS) WITHOUT TREATMENT DELAY FOR CYTOPENIA - A NEW STANDARD IN PRE-AUTOGRAFT REMISSION INDUCTION FOR RELAPSED OR REFRACTORY HODGKIN'S DISEASE?
http://online.haematologica.org/eha13/browserecord.php?-action=browse&-recid=2173


Gemcitabine, Dexamethasone, and Cisplatin (GDP) Is An Effective and Well-Tolerated out-Patient Salvage Therapy for Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) and Hodgkin Lymphoma (HL)
http://ash.confex.com/ash/2010/webprogram/Paper32244.html
 

HDMTX

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High dose Methotrexate (Rheumatrex®) Antimetabolites Details ptmd.com

hyperCVAD

or

R-hyperCVAD

 
now with Rituxan 
for MCL

Related abstracts

Hyper CVAD Followed by SCT for MCL - PubMed

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==

C = twice daily Cyclophosphamide (Cytoxan®) DNA-Altering
V = Vincristine (Oncovin®) Blocks Cell Duplication
A = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
D = Dexamethasone steroidal: anti-inflammatory, Immunosuppressant

R- Rituxan- a monoclonal antibody is commonly added to chemotherapy protocols


The above is alternated with high dose Methotrexate, and Ara-C .
    Ara-C®, Cytosar®) Antimetabolites
    Methotrexate (Rheumatrex®) Antimetabolites

"The hyperCVAD regimen actually involves two regimens. The hyperCVAD combination is alternated with high doses of methotrexate and cytarabine for four courses. Then high-dose cyclophosphamide and total-body irradiation are followed by autologous stem cell transplantation." - MDACC
 

bullet
About the hyperCVAD protocol- cancercare.on.ca PDF 
 
Treatment schedule, side effects, monitoring ...
bullet
Mantle cell lymphoma (MCL): Induction therapy with HyperCVAD/High-dose methotrexate and cytarabine (M-C) (±rituximab) improves results of autologous stem cell transplant in first remission. - ASCO 2006 

 

ICE

 

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==

TOPIC SEARCH on outcomes: ASCO | Medscape | PubMed | Web 
on risks: ASCO | Medscape | PubMed | Web 

I = Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin (Paraplatin®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor

R-ICE

Rituximab and ICE (RICE) as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma  bloodjournal

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R = Rituxan- Monoclonal antibody against CD20
I = Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin (Paraplatin®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor

IMVP-16

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I = Ifosfamide (Ifex®) DNA-Altering
M = Methotrexate (Rheumatrex®) Antitumor Antibiotic
VP = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor

MACOP-B

Related abstracts
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M = Methotrexate (Rheumatrex®) Antimetabolites
A = Doxorubicin (Adriamycin®, Rubex®) Antitumor Antibiotic
C = Cyclophosphamide (Cytoxan®) DNA-Altering
O = Vincristine (Oncovin ®) Blocks Cell Duplication
P = Prednisone (Deltasone ®) steroidal: anti-inflammatory, Immunosuppressant
B = Bleomycin (Blenoxane ®) Antitumor Antibiotic

MOPP/ABV

Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin's disease: report of an intergroup trial. J Clin Oncol. 2003 Feb 15;21(4):607-14.
PMID: 12586796 - PubMed

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(MOPP)
M = Mechlorethamine,
V =
Vincristine
P = Procarbazine 
P = Prednisone

(ABVD) 
A =
Doxorubicin
B = Bleomycin 
V = Vinblastine 
D = Dacarbazine 

M-BACOD

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M = Methotrexate (Rheumatrex®) Antimetabolites: interfers with normal growth
B = Bleomycin (Blenoxane®)
Antitumor Antibiotic
A =
Doxorubicin (Adriamycin®, Rubex®) Antitumor Antibiotic
C = Cyclophosphamide (Cytoxan®)
DNA-Altering
V =
Vincristine (Oncovin®) Blocks Cell Duplication
D = Dexamethasone
steroidal: anti-inflammatory, Immunosuppressant

O-DICE

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SALVAGE: Phase II study of dexamethasone, ifosfamide, cisplatin and etoposide delivered on an outpatient basis (O-DICE), as salvage chemotherapy for patients with relapsed and refractory lymphoma Year: 2002 Abstract No: 1136

PEP-C
Abstract

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P = Prednisone (Deltasone®)
E =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
P = Procarbazine (Matulane®)
C= Cyclophosphamide (Cytoxan®) DNA-Altering

PMitCEBO

 

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P = Prednisone (Deltasone®) steroidal: anti-inflammatory, Immunosuppressant 
Mit = Mitoxantrone ( mye-toe-ZAN-trone)  DNA intercalation; DNA topoisomerase II inhibition 
C = Cyclophosphamide (Cytoxan®) DNA-Altering 
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor 
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
O = Vincristine (Oncovin®) Blocks Cell Duplication

A phase III trial comparing CHOP to PMitCEBO with or without G-CSF in patients aged 60 plus with aggressive non-Hodgkin's lymphoma. Br J Cancer. 2006 Mar 27;94(6):806-13. PMID: 16508640

Pro-MACE
- CytaBOM

 

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Prednisone (Deltasone®) 
Methotrexate (Rheumatrex®)
Antimetabolites: interferes with normal growth
Doxorubicin (Adriamycin®, Rubex®) Antitumor Antibiotic
Cyclophosphamide (Cytoxan®)
DNA-Altering
Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
Cytarabine (Ara-C', Cytosar®)
Antimetabolites: interfers with normal growth
Bleomycin (Blenoxane®)
Antitumor Antibiotic
Vincristine (Oncovin®) Blocks Cell Duplication

R-PACEBOM

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PACEBOM "comprising oral prednisolone together with intravenous doxorubicin, cyclophosphamide and etoposide alternating weekly with intravenous bleomycin, vincristine and methotrexate."  R-PACEBOM includes also Rituxan

See for PubMed abstracts: http://www.ncbi.nlm.nih.gov/pubmed?term=PACEBOM

RICE

Rituximab and ICE (RICE) as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma  bloodjournal

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R = Rituxan- Monoclonal antibody against CD20
I = Ifosfamide (Ifex®)
DNA-Altering
C = Carboplatin (Paraplatin®) DNA-Altering
E = Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor

VBM

Efficacy of vinblastine, bleomycin, methotrexate (VBM)  chemotherapy with involved field radiotherapy in early stage (I-IIA) Hodgkin disease patients. Leuk Lymphoma. 2003 Nov;44(11):1919-23. Review. PMID: 14738143 | Related articles

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==

V = Vinblastine (Oncovin®) Blocks Cell Duplication
B = Bleomycin, (Blenoxane®)
Antitumor Antibiotic
M = Methotrexate (Rheumatrex®)
Antimetabolites: interferes with normal growth

 
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