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Treatment
Overview or Chemotherapy >
Common combinations
Last update:
09/16/2012
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APO
Abstracts |
== A
=
Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
P = Prednisolone
O =
Vincristine (Oncovin®) Blocks Cell Duplication
and Methotrexate
(substituted for Doxorubincin when toxicity threshold is reached.) |
ATT
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==
Alternating Triple Therapy. The protocol involves a sequence
of three regimens, CHOD-Bleo, ESHAP, and NOPP. The drugs in these
regimens include:
cyclophosphamide, doxorubicin, vincristine,
belomycin, VP-16, cisplatin, mitoxantrone, procarbazine, and corticosteriods (prednisone, methylprednione,
dexamethasone.) The only overlap with FND is the mitoxantrone and dexamethasone.
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BEAM Mini
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== B
= Carmustine (BCNU®) DNA-Altering
E =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme
Inhibitor
A = Cytarabine (Ara-C®, Cytosar®) Antimetabolites
M = Melphalan (Alkeran®) DNA-Altering
Details on BEAM: spitfire.emmes.com
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Bendamustine Treanda
Bendamustine
(SDX-105)
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== B
= Bendamustine (bifunctional agent with both alkylator and purine-like
activity)
R- Rituxan- a monoclonal antibody is
commonly added to chemotherapy protocols
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BEAC
BEAC
or BEAM?
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== B
= Carmustine (BCNU®) DNA-Altering
E =
Etoposide (VP-16, VePesid ®) DNA Repair Enzyme
Inhibitor
A = Cytarabine (Ara-C®, Cytosar®) Antimetabolites
While BEAC and BEAM appears to have equal antitumour
efficacy in patients with NHL, BEAM seems to be more toxic to the
gastrointestinal tract. However, randomized studies are needed for more
definitive conclusions on the relative merits of various high-dose
regimens in patients with NHL. PMID:
12916867
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CHOP
CHOP + R
For aggressive or
indolent lymphoma
Abstracts
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==
Dr. Sharman's CLL & Lymphoma Blog What is R-CHOP? C
=
Cyclophosphamide
(Cytoxan®) DNA-Altering
H =
Doxorubicin (Adriamycin®) or Rubex® or Hydroxydaunomycin Antitumor
Antibiotic
O =
Vincristine (Oncovin®) Blocks Cell Duplication
P =
Prednisone (Deltasone®) steroidal:
anti-inflammatory, Immunosuppressant
R- Rituxan- a monoclonal antibody is
commonly added to chemotherapy protocols
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CEOP-R
CHOP-like chemotherapy
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== C
=
Cyclophosphamide
(Cytoxan®) DNA-Altering
O =
Vincristine (Oncovin®) Blocks Cell Duplication
E = Epirubicin Epirubicin, anthracycline
drug nlm.nih.gov
P =
Prednisone (Deltasone®) steroidal:
anti-inflammatory, Immunosuppressant |
CODOX-M
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== C
=
Cyclophosphamide
(Cytoxan®) DNA-Altering
O =
Vincristine (Oncovin®) Blocks Cell Duplication
D = Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
M = Methotrexate (Rheumatrex®) Antitumor Antibiotic |
COPBLAM
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== C
=
Cyclophosphamide
(Cytoxan®) DNA-Altering
O =
Vincristine (Oncovin®) Blocks Cell Duplication
P = Prednisone (Deltasone®) steroidal:
anti-inflammatory, Immunosuppressant
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
A =
Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
M = Procarbazine (Matulane®) DNA-Altering |
CP
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C
= Chlorambucil
(Leukeran®) DNA-Altering
P = Prednisone (Deltasone®) steroidal:
anti-inflammatory, Immunosuppressant |
CVP
CVP + R
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== C
=
Cyclophosphamide
(Cytoxan®) DNA-Altering
V =
Vincristine (Oncovin®) Blocks Cell Duplication
P =
Prednisone (Deltasone®) steroidal:
anti-inflammatory, Immunosuppressant
R = Rituxan
- Monoclonal antibody against CD20 (addition of Rituxan has become
standard)
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CyMiR
Abstracts
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== C
=
Cyclophosphamide
(Cytoxan®) DNA-Altering
Mitoxantrone Mitoxantrone (Novantrone®) Antitumor Antibiotic
Rituxan |
DHAP
Abstracts
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== D
=
Dexamethasone
(Decadron®) steroidal:
anti-inflammatory, Immunosuppressant
HA =
Cytarabine (Ara-C, Cytosar®) Antimetabolites
P =
Cisplatin (Platinol®) DNA-Altering
R- Rituxan- a monoclonal antibody is
commonly added to chemotherapy protocols
Oxaliplatin Appears Effective (as cisplatin in DHAP
& safer) in Treatment Regimen for Recurrent NHL
CancerConsultants.com
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DICE
Abstract
ncbi.nlm.nih.gov
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== D
= Dexamethasone
(Decadron®) steroidal:
anti-inflammatory, Immunosuppressant
I = ifosfamide (ifek®) DNA-Altering
C =
Cisplatin (Platinol®) DNA-Altering
E =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
R- Rituxan- a monoclonal antibody is
commonly added to chemotherapy protocols
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EPOCH
Abstracts
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==
E
=
Etoposide (VP-
16, VePesid®) DNA Repair Enzyme Inhibitor
P =
Prednisone (Deltasone®) steroidal:
anti-inflammatory, Immunosuppressant
O =
Vincristine (Oncovin®) Blocks Cell Duplication
C = Cyclophosphamide (Cytoxan®) DNA-Altering
H = Doxorubicin (Adriamycin®) Antitumor Antibiotic
R- Rituxan- a monoclonal antibody is
commonly added to chemotherapy protocols
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ESHAP
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== E
=
Etoposide (VP-16, VePesid®) DNA Repair Enzyme Inhibitor
S = Methylprednisolone
(Medrol®) steroidal: anti-inflammatory,
Immunosuppressant
HA =
Cytarabine
(Ara-C®, Cytosar®) Antimetabolites
P =
Cisplatin(Platinol®) ) DNA-Altering
R- Rituxan- a monoclonal antibody is
commonly added to chemotherapy protocols
Alert: Severe hypomagnesaemia
(low magnesium) with tetany following ESHAP protocol - http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=64621
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Fludarabine
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==
Fludarabine (Fludara ®) Antimetabolites
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Fludarabine
+ Rituxan
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== F = Fludarabine (Fludara ®) Antimetabolites
R = Rituxan
- Monoclonal antibody against CD20
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FCR
Related
PubMed articles: Follicular outcomes
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== F=
Fludarabine
(Fludara ®) Antimetabolites
C = Cyclophosphamide (Cytoxan®) DNA-Altering
R = Rituxan- Monoclonal antibody against CD20
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FND
FND + R
or R-FND
Abstracts
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== F=
Fludarabine
(Fludara ®) Antimetabolites
D= Dexamethasone steroidal:
anti-inflammatory, Immunosuppressant
R = Rituxan- Monoclonal antibody against CD20
Also see:
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FCM+R
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== F=
Fludarabine
(Fludara ®) Antimetabolites
C = Cyclophosphamide (Cytoxan®) DNA-Altering
M =
Mitoxantrone ( mye-toe-ZAN-trone) DNA intercalation; DNA topoisomerase II inhibition
R = Rituxan- Monoclonal antibody against CD20
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GDP
Abstracts
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Gemcitabine, dexamethasone and cisplatin is an active
and
non-toxic chemotherapy regimen in relapsed or refractory
Hodgkin’s disease: a phase II study by the National Cancer
Institute of Canada Clinical Trials Group
http://annonc.oxfordjournals.org/content/14/12/1762.full.pdf+html
[Efficacy of GDP regimen (gemcitabine, dexamethasone, and cisplatin) on
relapsed or refractory aggressive non-Hodgkin's Lymphoma: a report of 24
cases].
http://www.ncbi.nlm.nih.gov/pubmed/19000458
INTERMEDIATE DOSE GEMCITABINE - CISPLATIN COMBINATION CHEMOTHERAPY (GEMCIS)
WITHOUT TREATMENT DELAY FOR CYTOPENIA - A NEW STANDARD IN PRE-AUTOGRAFT
REMISSION INDUCTION FOR RELAPSED OR REFRACTORY HODGKIN'S DISEASE?
http://online.haematologica.org/eha13/browserecord.php?-action=browse&-recid=2173
Gemcitabine, Dexamethasone, and Cisplatin (GDP) Is An Effective and
Well-Tolerated out-Patient Salvage Therapy for Relapsed/Refractory Diffuse
Large B-Cell Lymphoma (DLBCL) and Hodgkin Lymphoma (HL)
http://ash.confex.com/ash/2010/webprogram/Paper32244.html
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HDMTX
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==
High
dose Methotrexate (Rheumatrex®) Antimetabolites
Details ptmd.com |
hyperCVAD
or
R-hyperCVAD
now with Rituxan
for MCL
Related
abstracts
Hyper CVAD Followed by SCT for MCL - PubMed
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== C = twice daily
Cyclophosphamide (Cytoxan®) DNA-Altering
V =
Vincristine (Oncovin®) Blocks Cell Duplication
A =
Doxorubicin (Adriamycin®) Rubex® Antitumor Antibiotic
D = Dexamethasone steroidal:
anti-inflammatory, Immunosuppressant
R- Rituxan- a monoclonal antibody is
commonly added to chemotherapy protocols
The above is alternated
with high dose Methotrexate, and Ara-C
.
Ara-C®, Cytosar®) Antimetabolites
Methotrexate (Rheumatrex®) Antimetabolites
"The
hyperCVAD regimen actually involves two regimens. The hyperCVAD
combination is alternated with high doses of methotrexate and cytarabine
for four courses. Then high-dose cyclophosphamide and total-body
irradiation are followed by autologous stem cell transplantation." - MDACC
.gif) |
About the hyperCVAD protocol- cancercare.on.ca
PDF
Treatment schedule, side effects, monitoring ...
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Mantle cell lymphoma (MCL): Induction therapy with HyperCVAD/High-dose
methotrexate and cytarabine (M-C) (±rituximab) improves results of
autologous stem cell transplant in first remission. - ASCO
2006
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ICE
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==
 TOPIC
SEARCH on outcomes: ASCO
| Medscape
| PubMed
| Web
on risks: ASCO
| Medscape
| PubMed
| Web
I
= Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin
(Paraplatin®) DNA-Altering
E =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme
Inhibitor
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R-ICE
Rituximab and ICE (RICE) as
second-line therapy before autologous stem cell transplantation for relapsed
or primary refractory diffuse large B-cell lymphoma
bloodjournal
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== R
= Rituxan- Monoclonal antibody against CD20
I = Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin
(Paraplatin®) DNA-Altering
E =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme
Inhibitor
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IMVP-16
|
== I
= Ifosfamide
(Ifex®) DNA-Altering
M = Methotrexate
(Rheumatrex®) Antitumor Antibiotic
VP =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme
Inhibitor |
MACOP-B
Related
abstracts
|
== M
= Methotrexate
(Rheumatrex®) Antimetabolites
A =
Doxorubicin (Adriamycin®, Rubex®) Antitumor
Antibiotic
C = Cyclophosphamide (Cytoxan®) DNA-Altering
O =
Vincristine (Oncovin ®) Blocks Cell Duplication
P = Prednisone (Deltasone ®) steroidal:
anti-inflammatory, Immunosuppressant
B = Bleomycin (Blenoxane ®) Antitumor Antibiotic |
MOPP/ABV
Randomized comparison of ABVD and MOPP/ABV hybrid for the
treatment of advanced Hodgkin's disease: report of an intergroup
trial. J Clin Oncol. 2003 Feb 15;21(4):607-14.
PMID: 12586796 - PubMed
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==
(MOPP)
M = Mechlorethamine,
V =
Vincristine
P = Procarbazine
P = Prednisone
(ABVD)
A =
Doxorubicin
B = Bleomycin
V = Vinblastine
D = Dacarbazine |
M-BACOD
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== M
= Methotrexate
(Rheumatrex®) Antimetabolites: interfers with
normal growth
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
A =
Doxorubicin
(Adriamycin®, Rubex®) Antitumor
Antibiotic
C = Cyclophosphamide (Cytoxan®) DNA-Altering
V =
Vincristine
(Oncovin®) Blocks Cell Duplication
D = Dexamethasone steroidal:
anti-inflammatory, Immunosuppressant |
O-DICE
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== SALVAGE: Phase II study of dexamethasone, ifosfamide, cisplatin
and etoposide delivered on an outpatient basis (O-DICE), as salvage
chemotherapy for patients with relapsed and refractory lymphoma Year:
2002 Abstract No: 1136 |
PEP-C
Abstract
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== P
=
Prednisone (Deltasone®)
E =
Etoposide
(VP-16, VePesid®) DNA Repair Enzyme Inhibitor
P = Procarbazine (Matulane®)
C= Cyclophosphamide (Cytoxan®) DNA-Altering |
PMitCEBO
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== P = Prednisone (Deltasone®) steroidal:
anti-inflammatory, Immunosuppressant
Mit = Mitoxantrone ( mye-toe-ZAN-trone) DNA intercalation; DNA topoisomerase II inhibition
C = Cyclophosphamide (Cytoxan®) DNA-Altering
E =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme
Inhibitor
B = Bleomycin (Blenoxane®) Antitumor Antibiotic
O =
Vincristine (Oncovin®) Blocks Cell Duplication
A phase III trial comparing CHOP to PMitCEBO with or without G-CSF
in patients aged 60 plus with aggressive non-Hodgkin's lymphoma.
Br J Cancer. 2006 Mar 27;94(6):806-13.
PMID:
16508640
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Pro-MACE
- CytaBOM
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==
Prednisone (Deltasone®)
Methotrexate (Rheumatrex®) Antimetabolites:
interferes with normal growth
Doxorubicin
(Adriamycin®, Rubex®) Antitumor
Antibiotic
Cyclophosphamide (Cytoxan®) DNA-Altering
Etoposide
(VP-16, VePesid®) DNA Repair Enzyme
Inhibitor
Cytarabine (Ara-C', Cytosar®) Antimetabolites:
interfers with normal growth
Bleomycin (Blenoxane®) Antitumor Antibiotic
Vincristine
(Oncovin®) Blocks Cell Duplication
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R-PACEBOM
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PACEBOM "comprising oral prednisolone together with intravenous
doxorubicin, cyclophosphamide and etoposide alternating weekly with
intravenous bleomycin, vincristine and methotrexate." R-PACEBOM
includes also Rituxan See for PubMed abstracts:
http://www.ncbi.nlm.nih.gov/pubmed?term=PACEBOM
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RICE
Rituximab and ICE (RICE) as
second-line therapy before autologous stem cell transplantation for relapsed
or primary refractory diffuse large B-cell lymphoma
bloodjournal
|
==
R
= Rituxan- Monoclonal antibody against CD20
I = Ifosfamide (Ifex®) DNA-Altering
C = Carboplatin
(Paraplatin®) DNA-Altering
E =
Etoposide (VP-16, VePesid®) DNA Repair Enzyme
Inhibitor
|
VBM
Efficacy of
vinblastine, bleomycin, methotrexate (VBM) chemotherapy with involved field radiotherapy in early stage
(I-IIA)
Hodgkin disease patients. Leuk Lymphoma. 2003 Nov;44(11):1919-23.
Review. PMID:
14738143 | Related
articles
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==
V = Vinblastine (Oncovin®)
Blocks Cell Duplication
B = Bleomycin, (Blenoxane®) Antitumor Antibiotic
M = Methotrexate (Rheumatrex®) Antimetabolites: interferes with
normal growth |
