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Clinical Trials >  Find Trials By Type of Targeted Agent

Monoclonal antibody | Bispecific antibody | Conjugated antibody | Radioimmunotherapy | Cytotoxic |
Immune mediated | Targeted: Epigenetic |  BCL-2 | kinase inhibitors | mTOR ... | (Click Report) |

TIP: After clicking the desired query, click the Results on Map tab to find studies in your region

Last update: 04/25/2012

Agent

 		 B or T cell 
 		 Target
of Drug
 		 Approved
Indication
 

Queries

Locate
Studies on
ClinicalTrials.gov

 

 Initial Count

as of 12/4/11

2,077
 		 Counting
Visitor Clicks
as of
1/4/11

Total:
2,282		 Find
Clinical Reports
on Agent

Google
Scholar
 		 Class
(Search)

 

Monoclonal antibodies

Binding one receptor expressed on tumor cells
 
Arzerra (Ofatumumab)		 B cd20 CLL http://bit.ly/91zoO5   133 Reports antibody, monoclonal - cd20
 Rituxan (Rituximab / Mabthera) B cd20 NHL http://bit.ly/6xyt9z   40 Reports antibody, monoclonal - cd20
GA-101 (Obinutuzumab /type II) B cd20 - http://bit.ly/hQyC5a   212 Reports antibody, monoclonal - cd20
Veltuzumab / Immu-106 / Ha20 B cd20 - http://bit.ly/iaB55z   8 Reports antibody, monoclonal - cd20
Epratuzumab B cd22 - http://bit.ly/5yep4r   46 Reports antibody-monoclonal-cd22
Lumiliximab B cd23 - http://bit.ly/5Qr0ft   25 Reports monoclonal antibody
SGN-30 B / T cd30 - http://bit.ly/4DxclV   33 Reports monoclonal antibody
TRU-016) B cd37 - http://bit.ly/5dRM68   39 Reports monoclonal antibody
Zanolimumab T cd4 - http://bit.ly/7VX1vb   43 Reports monoclonal antibody
Campath (alemtuzumab) B cd52 CLL http://bit.ly/7gEbxH   21 Reports monoclonal antibody
MDX-1411 B / T cd70 - http://bit.ly/7GbSR5   21 Reports monoclonal antibody
Milatuzumab / hLL1 B cd74 - http://bit.ly/657qo4   29 Reports monoclonal antibody
KW-0761 T CCR4 - http://bit.ly/c4uS6R   30 Reports monoclonal antibody
CT-011 B PD-1 (P7) - http://bit.ly/1Bj7r1   131 Reports monoclonal antibody

Bispecific antibodies

Binding two receptors expressed on tumor cells
Bispecific antibody + immunotoxin (DT2219ARL) B cd19 cd22 - http://bit.ly/788Vpv   60 Reports

Bispecific antibody
Bispecific antibody
(BiTe / Blinatumomab / MT103)		 B cd3 cd19 - http://bit.ly/gPYMVQ   35 Reports

Bispecific antibody

Conjugated antibody

Delivering toxins via an antibody mainly to tumor cells
antibody + maytansinoid
(SAR3419)		 B cd19 - http://bit.ly/4ERMLb 61 66 Reports conjugated antibody 
bispecific  antibody + immunotoxin (DT2219ARL) B cd19 cd22 - http://bit.ly/788Vpv 28 35 Reports

Bispecific antibody
antibody + calicheamicin
(Inotuzumab Ozogamicin)		 B cd22 - http://bit.ly/8Bzg5Z  102 108 Reports conjugated antibody
CD25 antibody + immunotoxin
(LMB-2 immunotoxin)		 B cd25 - http://bit.ly/5oEStJ  20 20 Reports conjugated antibody
antibody + antitubulin
Adcetris (SGN-35 / brentuximab vedotin)		 - cd30 HD /ALCL http://bit.ly/618Lg7 99 114 Reports conjugated antibody
IL-2 antibody + toxic protein
(Ontak / Denileukin diftitox)		 B IL2 receptor cutaneous
t-cell		 http://bit.ly/hFuenl  1 1 Reports conjugated antibody

Radio-immunotherapy

Delivering radiation via an antibody mainly to tumor cells
antibody + iodine 131
Bexxar (Tositumomab, Iodine I 131)		 B cd20 NHL http://bit.ly/4RYDEO 32 36 Reports

Radioimmunotherapy
antibody + Yttrium 90
Zevalin (Ibritumomab tiuxetan)		 B cd20 NHL http://bit.ly/6Kaq6R  39 44 Reports

Radioimmunotherapy
antibody with  fractionated Yttrium 90
(epratuzumab tetraxetan)		 B cd22 - http://bit.ly/getBGq  12 41 Reports

Radioimmunotherapy

Cytotoxic Agents

Damaging mainly dividing cells
cytotoxic
Treanda (Bendamustine)		 B DNA NHL/CLL http://bit.ly/cYUZ9E 52 53 Reports

cytotoxic
cytotoxic
Folotyn (Pralatrexate)		 - DNA T-cell http://1.usa.gov/vHm55d 0 0 Reports

cytotoxic
cytotoxic
(Pixantrone)		 B DNA - http://1.usa.gov/sOAp2L 0 0

Reports

cytotoxic

Immune-mediated

Altering immunity to fight cancer cells
Lenalidomide 
(Revlimid (r) / CC-5013)		 B   MDS http://bit.ly/9ey9yc 42 51 Reports

Immune modulating
Engineered t-cell therapy
(CART19)		 B cd19 - http://1.usa.gov/n03Upb 67 72 Reports

t-cell therapy
vaccine B tumor antigen - http://1.usa.gov/so7cBq 0 7 Reports

therapeutic vaccine

Targeted Agents

     

Epigenetic Modulation

Reprogramming (turning on/off) expression of genes in tumor cells
such as by methylation of histones
    Target            
Vidaza® (5-Azacytidine) B DNA hypo-methylation MDS http://bit.ly/dlP4v9 7 10 Reports

epigenetic

HDAC inhibition

Interfere with the function of histone deacetylase by
control the coiling and uncoiling of DNA around histones.
Panobinostat (LBH589) T or B     http://bit.ly/cknlCH 19 19 Reports

HDAC
Romidepsin (Depsipeptide) T or B   T-cell http://1.usa.gov/yO9lkg  16 23 Reports

HDAC
Valproic acid T or B   AML / MDS http://bit.ly/4yx3VU 69 70 Reports

HDAC
Zolinza (Vorinostat) > T or B   T-cell http://bit.ly/aFsxvB 64 64 Reports

HDAC

Other

Binding pathways (signals in cells) that are over-expressed in tumor cells

BCL-2 inhibitors

   Target            
Navitoclax / ABT-263 B bcl-2
pathway		 - http://bit.ly/5fcv13 70 80 Reports

targeted
Obatoclax mesylate / GX15-070) B bcl-2
pathway		 - http://bit.ly/gGCnFX 25 27 Reports

targeted

mTOR

   Target            
Everolimus / RAD001 (oral) B mTOR - http://bit.ly/9y8d43 20 21 Reports

targeted
Temsirolimus / CCI-779 (IV) B mTOR - http://bit.ly/bOHVqB 16 22 Reports

targeted

Kinase inhibitors

   Target            
MLN8237
 B Aurora Kinase A - http://1.usa.gov/yaZQ2G 0   Reports  
 
(Enzastaurin /LY317615)		 B C-beta - http://1.usa.gov/ubBXOp 0 3 Reports

targeted
 
CAL-101 (GS-1101) >		 B PI3k delta - http://bit.ly/c9MoqC 273 287 Reports

targeted

AVL-292		 B Bruton's tyrosine (Btk)   http://1.usa.gov/w31ojR     Reports

targeted

PCI-32765 >
 (ibrutinib [eye broo' ti nib])   		B Bruton's tyrosine (Btk)   http://1.usa.gov/v6ZncS 9 104 Reports

targeted

Other

   Target            
YM155 B survivin kinase - http://bit.ly/6XTWRh 44 45 Reports

targeted
                 

See also Find Clinical Trials based on Type of Lymphoma and Clinical Circumstance
 
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