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Radiation therapy or chemotherapy
destroys
megakaryocytic, the precursor cells that produce platelets in the
bone marrow. Topic search:
Medscape
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Genetic abnormalities, may impair production of normal platelets. |
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A cancer, such as lymphoma, in the bone marrow can inhibit production of platelets. |
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Aplastic anemia can impair platelet production. |
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Certain drugs, especially thiazide diuretics or alcohol, depresses production of precursor cells that produce platelets in the bone marrow. |
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Short-term low platelets is also associated with some viral infection. |
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Autoimmune disease called Idiopathic thrombocytopenic purpura (ITP) can cause the body to destroy platelets. Other autoimmune diseases, such as systemic lupus erythematosus (SLE), polyarteritis and dermatomyositis, can cause thrombocytopenia. |
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In individuals with AIDS, thrombocytopenia commonly appears before other symptoms. |
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Drug-induced thrombocytopenia can be caused by any medication commercially available, but somewhat frequently by valproic acid (Depakote), gold salts, heparin (Calciparine, Liquaemin) and several other medications. |
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Thrombotic thrombocytopenic purpura (TTP) — a rare disease that causes low platelets, in addition to a variety of other symptoms and complications. See itppeople.com | acor.org |
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"Individuals with liver disease develop a large spleen. As this process occurs platelets are trapped with in the sinusoids (small pathways within the spleen) of the spleen. While the trapping of platelets is a normal function for the spleen, in liver disease it becomes exaggerated because of the enlarged spleen (splenomegaly). Subsequently, the platelet count may become diminished." - http://www.gastromd.com/lft.html |
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Abnormalities in the spleen, such as cancer, cirrhosis, or Gaucher's disease, may cause abnormal amounts of platelets to be taken up by the spleen, which under normal conditions contains about one-third of the platelets in the body. |
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About thrombocytopenia intelihealth.com |
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About platelet transfusions cancerbackup.org.uk |
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Managing Low Platelets
lrcc.on.ca
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Platelet Transfusion for Patients With Cancer - ASCO.org |
Makes you susceptible to bleeding
Approximate normal range:
130-400 (x109/l)
Normal range may vary for different labs
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Platelets: Thrombotic Thrombocytopenic Purpura - Comprehensive review asheducationbook.org |
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Hemoglobin blood test MedlinePlus |
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Autoimmune thrombocytopenia associated with the first cycle of fludarabine therapy in the treatment of relapsed non-Hodgkin's lymphoma PubMed |
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B-cell depletion with rituximab as treatment for immune hemolytic anemia and chronic thrombocytopenia. Haematologica. 2002 Feb;87(2):189-95. PubMed |
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Drug info: Neumega |
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ITP - Immune (Idiopathic) Trombocytopenic Purpura -
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Help with platelet recovery? Use of
physiological doses of human growth hormone in haematological
patients receiving intensive chemotherapy promotes haematopoietic
recovery: a double-blind randomized, placebo-controlled study
PubMed
2007
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Disclaimer: The information on Lymphomation.org is not intended to be a
substitute for
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