Tests & Imaging > Diagnostic Tests > Bone Marrow Biopsy and Aspirate

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It's common to be diagnosed with lymphoma at an advanced stage (III or IV) and with bone marrow involvement. While this might seem alarming, you should know that advanced stages of lymphoma can be treated successfully, and that lymphoma in the bone marrow is as reversible as lymphoma anywhere in the body.

Ask your doctor to take additional steps to minimize the discomfort, such as taking the time to thoroughly anesthetize the area. 

NOTE:  Best to avoid blood thinners prior to having a surgical procedures,  such as  aspirin, fish oil, Vitamin E.

Talk to your doctor about medications and supplements you are taking.

Questions About Fear of BMB:

" I haven’t had one for almost a year. Before that I had had many, maybe 15 or so. They started out easy to take and progressively got worse to take. I am now TERRIFIED of them to the point where I hyperventilate and almost pass out. ...

That day the answers came pouring onto the list (BMT-Talk) from around the world and were still coming four days later. Others were posted privately to the man who had become terrified of bone marrow biopsies. Here are a few:

“Have you tried Versed? The best BMB I ever had was from my local hem/onc, who used Versed—I was kind of awake but felt & remembered nothing.”
 
“I second the vote for the Versed (with a little Demerol thrown in…).”
 
“…IV Diazepam is the intended drug. A short and mercifully deep sedation without actual anesthesia—and usually amnesia about the actual event. You really deserve this after excruciating BMBs.”
 
“Two Vicodans plus Atavin. I can’t say it didn’t hurt but it wasn’t nearly as bad as I thought it would be.”

Source: bmtinfonet.org

________________
 
Tony writes: I'm one of those folks who doesn't like to be awake for his BMB. My first one, just after being diagnosed, was fairly uncomfortable. Okay, it was damn uncomfortable and hurt quite a bit. I had it done at my local hospital. My second one was done at Mayo for the Genitope trial. They put me out for that one to harvest a node, and at the same time did the BMB.

My third BMB was needed for the Favrille trial in Chicago. I was able to get that done at my local hospital but told my doc I refused to have it done without some meds. I got some Vicodin to take an hour or so before the procedure, and I got 2 ml of Ativan by IV just before the procedure. Yeah that was sweet. Didn't feel a thing and did not remember a thing.

BMB number 4 was needed for my current trial. Again wanted some meds. This time just got Versad by IV and it worked great! Didn't feel a thing. Of course it's more involved when you get the meds by IV and you need to have someone to drive you home after. But for me it's worth it.

On the other hand, a few years back my 87 year old mom needed a BMB a few months before she died. I didn't say anything to her about my experience because I didn't want to worry her. After it was over I asked her how bad it was. She said it didn't hurt at all.

So, there's two opposing viewpoints.

~ Tony (Lymphomavaccine support list)

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Overview of the Bone Marrow Biopsy procedure

Q&A: 
 
Question: Why do you have to have so many bone marrow biopsies?  I had one 3-1/2 years ago.  When I asked about having another one, neither of my two Dr's  thought it was necessary.

Some Reasons for Bone Marrow Biopsies

At diagnosis of indolent lymphoma: to obtain a baseline bone marrow biopsy (bmb) and to be able to determine if abnormal cells are present, characterize them, and determine how much is there. An initial bmb for indolent lymphomas seems especially reasonable if the stage of disease is not widespread and the determination of involvement might tip the scale for one treatment approach or another. 

Let's say you've got localized disease and radiotherapy is considered. If bone marrow involvement is not found ( doesn't mean not present* ), then radiotherapy might be more reasonable.  

* Only positive findings are considered conclusive.  The chance of false negatives is rather high.

Also the degree of initial involvement might help determine how to monitor you and what treatments will be most appropriate ... initial Rituxan, perhaps, as Rituxan can be affective at clearing the marrow.

BMB to monitor indolent lymphoma: Ask your doctor if a bmb might not be indicated (given the discomfort and stress and expense) unless the findings will influence the timing or approach to treatment.  If you have no symptoms and your managing the disease, why look for it? 

BMB for unusual lab results: Your doctor might order a bmb if unusual or unexpected blood counts or markers are found that indicate disease progression in the marrow or abnormal blood cell generation.

BMB for monitoring response to treatment for aggressive lymphoma: We would think a bmb is indicated in this setting as the goal of treatment is cure and you have to be able to confirm (as best you can) you've got it all.

BMB and clinical trials:
Many trials require bmb before and after therapy to determine if the treatment has benefit there.  

Treatments that require prior BMB: Zevalin and Bexxar require bmb in advance of the therapy as too much involvement (> 25%) precludes the use of this type of treatment.

Question:  Can imaging be used to detect bone marrow involvement - or where to take the sample?

The practice of guiding bone marrow biopsies by imaging is not routine for lymphomas at this time. We are still searching for reports on this question.  

NOTE: We are seeking to verify the claims made above.