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Patients Against Lymphoma

 

Advocacy >  T-Cell therapies
 

Last update: 09/13/2016

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PubMed - Related articles


Find T-cell therapy AND lymphoma ClinicalTrials.gov


Overview

T-cell therapy involves the programming or activation of specialized cells (T-cells) in the immune system that are capable of killing cancer cells. Depending on the type of T-cell therapy, the cells can be acquired from the patient or a donor.  When acquired from donors, it is called adoptive immunotherapy. 

T-cell therapy has been described as a "living drug" - combining the specificity of antibodies (targeting a molecule on the tumor such as cd10) with the killing power of t-cells. 

Efficacy of this approach is dependent on the ability of the enhanced cells to expand and persist in the body after being given to the patient by vein.  The safety of this treatment can be a concern as this approach can lead to serious inflammatory reactions.
 

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Chimeric Antigen Receptor T-cells (CARS)  Engineered T-cells Find trials


ImedexCME video: David Porter: University of  PA - CARs - A Living drug
Porter: presentation - CART Therapy for CLL - YouTube 
See also our topic page on CARS.

These are t-cells that are modified to target surface molecules on the tumor cell, such as cd19 or cd20.

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T Cells Targeting Multiple Tumor Associated Antigens

ASH report:  http://bit.ly/2ctiFSC

Video: T cells targeting multiple tumor-associated antigens in lymphoma http://bit.ly/2crhnEs

Studies: T Cells Targeting Multiple Tumor Associated Antigens - ClinicalTrials.gov


In the News

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ASH 15: Immunotherapy for
Lymphoma Using T Cells Targeting Multiple Tumor Associated Antigens http://bit.ly/2ctiFSC


 
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