|
Treatments or Chemotherapy >
Chemo agents & mechanisms
Last update: 04/18/2008
|
DNA-Altering
| Anti-tumor Antibiotics | Antimetabolites
| DNA Repair Enzyme Inhibitors |
Block Cell Duplication | Steroidal
Recommended Reading:
|
|
|
Cancer multidrug resistance (MDR)
- nature.com
|
"The
ability of chemotherapy to kill cancer cells depends on its
ability to halt cell division. Usually, the drugs work by
damaging the RNA or DNA that tells the cell how to copy itself
in division. If the cells are unable to divide, they die.
The faster the cells are dividing, the more likely it is that
chemotherapy will kill the cells, causing the tumor to shrink.
They also induce cell suicide (self-death or apoptosis)." -
chemocare.com
|
|
DNA-Altering Drugs
Alkylating agents:
DNA cross linking is a primary role of
agents
Replicating cells are most susceptible
to agents
Alkylating agents are not cell cycle
specific
fpnotebook.com
Also see Consequences and Targets of Alkylating Agents
- PDF
| PDF-Help
|
These drugs change DNA, the building block of cells, to prevent cell growth.
 |
|
|
|
|
|
|
|
|
 |
Evaluation of long-term toxicity in patients after
cisplatin-based chemotherapy for non-seminomatous testicular cancer
- PubMed
|
|
| Cyclophosphamide injection (Cytoxan®) - BCCancer
| Cancerbacup
|
| Cyclophosphamide oral (Cytoxan®) - BCCancer
|
|
|
|
|
|
Mechlorethamine (nitrogen mustard, Mustargen®) - BCCancer
| MedlinePlus
|
|
|
|
|
|
Anti-tumor Antibiotics
--
Interact with DNA and decrease
cell survival
Pegylated Liposomal doxorubicin in combination
chemotherapy in the treatment of previously untreated aggressive diffuse
large-B-cell lymphoma. Med Oncol. 2002;19(1):55-8.
PMID: 12025891 PubMed
| Related
Abstracts
|
These drugs interact with DNA and decrease
cell survival. Drugs that come from natural sources, such as plants or yeast, include
the following. Click link to read details.
|
Antimetabolites -
"Antimetabolites are very similar
to normal substances within the cell. When the cells incorporate
these substances into the cellular metabolism, they are unable to divide.
Antimetabolites are cell-cycle specific. They attack cells at very
specific phases in the cycle. Antimetabolites are classified
according to the substances with which they interfere." chemocare.com
|
These drugs interfere with normal cell growth.
|
DNA Repair Enzyme Inhibitors
|
These drugs act on certain proteins (enzymes) that normally work to repair faulty DNA
and therefore make cells more likely to die when they are injured.
|
Block Cell Duplication
--
Damage cell
structures that are required for a cell to divide
Microtubule inhibitors
|
These drugs damage cell structures required for cells to divide.
Vinorelbine is a vinca alkaloid that interferes with microtubule
assembly.
|
Targets
Proteasome
inhibits
proteasomal degradation
"The proteasomal degradation
pathway is essential for many cellular processes, including the cell
cycle, the regulation of gene
expression, and responses to oxidative
stress."
wikipedia
|
|
Steroidal
(Corticosteroids)
steroidal: anti-inflammatory, Immunosuppressant
|
Corticosteroids,
including Prednisone, Prednisolone, Methylprednisolone and
Dexamethasoneare are a group of synthetic hormones closely related to
cortisol (a glucocorticoid), a natural hormone produced in the adrenal
cortex.
"Prednisone
decreases inflammation by preventing white blood cells from functioning
properly. More specifically, the drug interferes with lymphocytes
(one of several types of white blood cells). The presence of
white blood cells result in inflammation (for many reasons, damage to
tissue, fungus, virus, bacteria, allergens and almost any foreign invader)
- they go to a site and their presence inflames the area. Prednisone
causes lymphocytes to break apart and die." Source: members.cox.net
Background:
|
Glucocorticoids Disease Mechanism II: Inflammation - Powerful Anti-inflammatory Compounds
- stanford.edu
|
|
Pretreatment with glucocorticoids enhances T-cell effector
function: possible implication for immune rebound accompanying
glucocorticoid withdrawal.
Cell Transplant. 1999 Nov-Dec;8(6):637-47. PMID:
10701493 | Related
abstracts
|
|
Mechanisms of anti-inflammatory action - Related
abstracts
|
|
Mechanisms of killing lymphoid cells - Related
abstracts
|
|
Overview & side
effects - About.com
|
|
