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Treatments > Chemo agents, Alphabetical Index
Last update: 04/30/2014
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A | B | C | D | E | F | G | H | I | J | K | L | M | N
O | P | Q | R | S | T | U | V | W | X | Y | Z
Also see Drug Indexes:
NCI Drug Index |  | Daily Meds database
Chemocare resources:
Chemotherapy drug index side effect information
Common Chemotherapy Acronyms, Regimens, and Abbreviations
A
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Adriamycin®, (Doxorubicin, Rubex®) Druginfo
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Ara-C (Cytarabine, Cytosine Arabinoside, Cytosar) Cancer.gov
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B
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Bendamustine (Treanda (r) ) Dailymed > Treatment abstracts | Cancer.gov | Scholar Search
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Full prescribing information http://www.treanda.com/pdf/TREANDA_final_PI.pdf
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Patient information: http://www.mayoclinic.com/health/drug-information/DR602629
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B-R vs. CHOP-R, Cheson - Medscape: Lymphoma: More a Question of Toxicity Than Efficacy
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Medscape: Is R-Benda a New Standard in Lymphoma? http://bit.ly/X5Azh5
video discussion by Dr Cheson
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Pivotal Study:
Bendamustine Plus Rituximab Is Superior to CHOP Plus Rituximab as First-Line Treatment of Patients with Advanced Follicular, Indolent, and Mantle Cell Lymphomas: Final Results of a Randomized Phase III Study of the StiL (Study Group Indolent Lymphomas, Germany) http://bit.ly/5CC1nt
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Bendamustine: Safety and Efficacy in the Management of Indolent NHL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117628/
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Treanda (Bendamustine) Full Prescribing information FDA PDF
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Side effects reported: ehealthme.com
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Onclive: What is best way to administer bendamustine (vesicant/irritant)? http://bit.ly/Vmm8zc
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Clinical Experience With Bendamustine: New Treatment for Patients With CLL: Dose and Administration Guidelines http://www.medscape.com/viewarticle/584893_6
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Bendamustine in Patients With Rituximab-Refractory Indolent and Transformed Non-Hodgkin's Lymphoma: Results From a Phase II Multicenter, Single-Agent Study http://jco.ascopubs.org/cgi/content/full/26/2/204
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Bendamustine (Treanda) For Chronic Lymphocytic Leukemia
A Brief Overview pubmedcentral.nih.gov
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Bendamustine, but not Fludarabine, - low stem cell toxicity in vitro. http://bit.ly/aOgmrR
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Bendamustine HCL for the treatment of relapsed indolent NHL http://bit.ly/cDZmsl (full text)
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Bendamustine for CNS involvement? http://jco.ascopubs.org/cgi/content/abstract/22/17/3608
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Bleomycin (Blenoxane®) SearchMedica
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brentuximab vedotin (Adcetris)
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Topic Search ncbi.nlm.nih.gov
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FDA Briefing Document
Oncologic Drugs Advisory Committee Meeting
July 14, 2011 | BLA 125388
(Adcetris) brentuximab vedotin
Proposed Indication: Treatment of Relapsed or Refractory Hodgkin Lymphoma
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Bexxar PAL | SearchMedica | Scholar Search
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C
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Carboplatin (Paraplatin®) Cancer.gov
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Carmustine (BCNU®) Cancer.gov
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Chlorambucil (Leukeran®) Druginfo.gov | DailyMeds.gov
Also see Treatment abstracts
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Chlorodeoxyadenosine (Cladribine®) MedlinePlus
Other names: 2-chlorodeoxyadenosine; 2-CdA
Cisplatin (Platinol®) Cancer.gov
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Cyclophosphamide injection (Cytoxan®) Cancer.gov
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Potential Immune-modulating effects of Cytoxan: PubMed query
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Cytarabine (cytosine arabinoside, Ara-C, Cytosar) Cancer.gov
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D
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Dacarbazine (DTIC®) BCCancer
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Deltasone® (Prednisone tablets) full prescribing information
www.pfizer.com/download/uspi_deltasone.pdf
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Dexamethasone (Decadron®) BCCancer
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Doxorubicin (Adriamycin®, Rubex®) DrugInfo.gov
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Doxorubicin, Liposomal (Doxil) Medline | cancer.gov
Full prescribing info from Doxil.com PDF
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E
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Etoposide IV (VP-16, VePesid®, Etopophos) Cancer.gov | Cancerbacup
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F
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Fludarabine IV (Fludara®) Full Prescribing Details
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What is FCR? http://bit.ly/PBQkI6
Dr. Sharman's CLL & Lymphoma Blog
An excellent explanation. A good read- even if your battle is not with CLL.
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Fludarabine oral (Fludara®) Cancer.gov
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G
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Gemcitabine (Gemzar®) Cancer.gov
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PubMed search:
Gemcitabine And Lymphoma ncbi.nlm.nih.gov | Treatment abstracts
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H
I
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Idarubicin (Idamycin®)
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Ifosfamide (ifex®)Lomustine (CCNU®) DrugInfo.gov
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J
K
L
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Leukeran® (Chlorambucil) Cancer.gov | Treatment abstracts
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Liposomal Doxorubicin (Doxil) chemocare.com
Full prescribing info from Doxil.com PDF | PDF-Help
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Liposomal vincristine (investigational) (Onco TSC) in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial. Ann Oncol. 2000 Jan;11(1):69-72. PMID: 10690390 PubMed | Abstracts
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M
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Mechlorethamine (nitrogen mustard, Mustargen®) BCCancer
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Melphalan (Alkeran®) BCCancer
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Mercaptopurine oral (Purinethol®) BCCancer
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Methotrexate oral (Rheumatrex®) BCCancer
Other name: amethopterin
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Methotrexate infusion BCCancer
Why does he need to have his system flushed after receiving the Methotrexate?
Andy wrote: Chemo is great for us when it is in the cancer cells. Pretty much everywhere else in the body, however, it is toxic. So, once it goes through the blood stream and starts moving into the kidneys and bladder, then you want to keep it moving along.
That's why you are supposed to stay well hydrated with chemo. While I haven't had methotrexate, I imagine that something very similar is the issue. I looked over the methotrexate prescribing info and it looks like there can be a lot of variability in how long it takes to clear out of the system and there are things they can help to flush it out and prevent damage to organs. How much of the 4 days is the infusion and then how much is the flushing time?
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Methylprednisolone (Medrol®) Medline
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Mitoxantrone full prescribing information:
www.osip.com/OSI/images/docs/NovantronePI1-2003.pdf | BCCancer
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Mitoxantrone (Novantrone®) BCCancer
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N
O
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ONTAK (denileukin diftitox) chemocare.com
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2012 - Ofatumumab - Chemoimmunotherapy with Ofatumumab in combination with CHOP in previously untreated follicular lymphoma onlinelibrary.wiley.com/
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P
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Pentostatin IV (Nipent®) Cancer.gov
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Pixantrone (investigational) (BR 2778): Alternative to Doxorubicin?
Might have similar activity against aggressive lymphomas as doxorubicin,
with less cardio toxicity Abstracts | Clinical trials
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Procarbazine (Matulane®) BCCancer
R
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Revlimid (Lenalidomide) - immune modulator druginfo.nlm.nih.gov
Full prescribing - dailymed.nlm.nih.gov
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Rituxan (immunotherapy) - PAL - abstracts
S
T
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Thalidomide  Topic Search | Cancer.gov
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Thioguanine oral (Lanvis®)
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Trofosfamide (palliative/elderly) as a salvage treatment with low toxicity in malignant lymphoma.
A phase II study. Eur J Cancer. 1997 Mar;33(3):500-2. PMID: 9155539 PubMed | Abstracts
U
V
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Vinblastine (Velban®)
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Vincristine (Oncovin®) Cancer.gov | Full Prescribing Document
NOTE: Adjusting the dose of Vincristine is common due to variable way individuals metabolize the drug and differences in half-life.
Clearance of the drug can vary from 23 to 85 hrs for adults;
and from 10 to 40 hrs in children. Source bccancer.bc.ca
Notify your doctor of symptoms associated with this drug.
"The neurotoxicity commonly manifests as ... constipation, and peripheral neuropathy which is predominantly sensory in nature. The early symptoms include numbness and tingling of hands and feet which is accompanied by loss of deep tendon reflexes. In its more severe form, muscle weakness develops which is more marked in distal muscles of the hands and feet. Other manifestations of neurotoxicity include ocular palsies, hoarseness of voice, and autonomic neuropathy in the form of postural hypotension and atony of the urinary bladder. The neurotoxicity is dose related and cumulative with repeated dosage such that the drug therapy has to be stopped after a cumulative dose of 30 to 50 mg. The neurotoxicity is usually reversible on interruption of the therapy, but the recovery is slow and takes several months. There are no specific antidotes which have established usefulness against neurotoxicity." PMID
Predicting toxicity? "Raised level of serum alkaline phosphatase may predict severe neurotoxicity" 1
1 Can severe vincristine neurotoxicity be prevented?
Cancer Chemother Pharmacol. 1982;8(2):211-4. PMID: 6125275 | Related Articles
Side effects of Vincristine, and when to inform your doctor:
Contact your doctor immediately, if
Fever over 100 degrees - indicating possible infection
Contact your doctor as soon as possible, if
Lower back or side pain - indicating possible kidney problems
Swelling of feet or lower legs
Gout-like joint pain
Changes in eye sight, blurry vision, or drooping eyelid
Trouble walking or climbing stairs
Severe constipation or stomach cramps
Difficulty urinating, or frequent need to urinate - bed-wetting
Contact your doctor when needed, if these symptoms continue to bother you
Uncontrolled nausea, vomiting, constipation or diarrhea
Easy bruising or bleeding
Severe jaw pain or headache
Redness, swelling, pain or sores where the needle was placed
Redness, swelling, pain or sores on your lips, tongue, mouth or throat
adapted from BCCancer
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Vincristine, liposomal (investigational) (Onco TSC) in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial. Ann Oncol. 2000 Jan;11(1):69-72. PMID: 10690390 PubMed | Abstracts
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Velcade approved for Multiple Myeloma will be available off label to patients with NHL Abstracts
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Background: Managing and avoiding bortezomib (Velcade) toxicity
Jeffrey Menashe, MD | Northwest Cancer Specialists, Portland, OR
communityoncology.net pdf
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Dietary flavonoids inhibit the anti-cancer effects of the proteasome inhibitor Bortezomib (Velcade)
Dietary flavonoids, quercetin and myricetin, which are abundant in plasma, inhibited Bortezomib-induced apoptosis of primary CLL and malignant B-cell lines in a dose-dependent manner.
Blood First Edition Paper, pre-published online
July 16, 2008; DOI 10.1182/blood-2008-04-150227.
Sources of flavonoids: http://lpi.oregonstate.edu/infocenter/phytochemicals/flavonoids/
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Vinorelbine (Navelbine®) FDA | Treatment abstracts
(Vinca alkaloid that interferes with microtubule assembly)
W
X
Y
Z
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Zevalin - PAL | Full prescribing information - Zevalin.com
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