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About
NHL > Types of Lymphoma > Large Cell Lymphomas
Last update: 04/24/2008
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Overview
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Large Cell Lymphomas
Generally fast growing cancer of b- or t-cells (lymphocytes) that normally
reside in the lymphatic system. Large Cell Lymphomas
(LCL) are one of the most common types of aggressive lymphoma,
comprising about 31% of lymphomas. These lymphomas appear in both children and adults.
What is lymphoma?
Briefly, lymphomas result when DNA
damage or changes occurs to an immune cell (a lymphocyte) that
alters the behavior of the cells. The damage to DNA results in the
abnormal production of proteins that prevents the cells from dying when
they should, or causes sustained rapid cell division that produces
more of its kind. These malignant cells
then may accumulate to form tumors that may enlarge the lymph nodes or
spread to other areas of the lymphatic
system, such as the spleen or
bone marrow.
The clinical and pathological features of non-Hodgkin's lymphomas are diverse. For example, there is large cell lymphoma and also intermediate grade or high grade lymphoma.
Diffuse Large B Cell Lymphoma accounts for for about
30% of all non Hodgkin lymphomas. It may first show itself as a
extra-nodal mass -- outside the lymphatic system -- or as a rapidly growing
nodal mass (enlarging lymph node).
See Diffuse
Cell Lymphoma page.
The characteristics of the lymphoma at
diagnosis as determined by the pathology report, and it's actual
clinical behavior, and other factors determine the type of treatment
and the timing of treatment you and your doctor will consider.
There are many types of large cell
lymphomas
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Lymphoma Series: Variants of Large-Cell Lymphoma theoncologist.alphamedpress.org
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PDF
Introduction to a Special Series of Unique Entities Within the Spectrum of Large-Cell Lymphoma, George P. Canellos, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
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| Large B-cell
lymphoma PubMed
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T Cell Rich Large B Cell Lymphoma
(a rare subtype of large B cell lymphoma)
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T-Cell/Histiocyte–Rich Large B-Cell Lymphoma: A Distinct
Clinicopathologic Entity By R. Achten jco.org
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T-Cell/Histiocyte-Rich Large B-Cell Lymphomas and Classical Diffuse Large B-Cell Lymphomas Have Similar Outcome After Chemotherapy: A Matched-Control Analysis
R. Bouabdallah,et al jco.org
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OTHER
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Intravascular B-cell
lymphomas (rare)
Report of two cases with different clinical presentation but rapid
central nervous system involvement. Leuk Lymphoma. 2003
Aug;44(8):1353-9.
PMID: 12952229 Abstracts
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Primary Mediastinal B-Cell Lymphoma
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Primary Splenic Lymphoma
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Angiocentric Lymphoma - Pulmonary B-Cell
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Anaplastic Large Cell Lymphoma
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Large-Cell, Immunoblastic
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B-cell stage: mature, after antigen exposure
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Lymphoblastic
lymphoma/
leukemia
B-cell stage: precursor
b-cell
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"Lymphoblastic
lymphoma. This lymphoma often occurs in young people. Associated
with large mediastinal mass (occurring in chest cavity between the
lungs) and carries a high risk for spreading to bone marrow and
central nervous system." healthnyt
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Treatment
Questions
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Patients Against Lymphoma
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| Aggressive Non-Hodgkin's Lymphoma: Improved
Prognosis With Combination Chemotherapy, Tables Medscape
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| Treatments of NHL (flowcharts) - MDACC PDF
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| Treatment Guidelines tsrcc.on.ca PDF
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